CAJ | 학술논문

目的探讨微量白蛋白尿(MAU)与代谢紊乱的关系.方法将250例人选患者根据代谢紊乱数量进行分组,检测各组患者的尿白蛋白排泄率(UAER)并计算MAU的阳性率,对比各组UAER和MAU阳性率之间的差异.结果 ①代谢综合征组患者的体质量指数、腰围、收缩压、舒张压、空腹血糖、胰岛素抵抗指数(HOMA-IR)、UAER、MAU的阳性率、三酰甘油和高敏C反应蛋白均高于对照组,高密度脂蛋白胆固醇水平低于对照组(P＜0.01);②随着代谢紊乱数量的增加UAER、MAU阳性率和HOMA-IR均进行性升高(P＜0.05,P＜0.01);1项及以下代谢异常患者与2项及以上代谢异常患者之间的MAU阳性率差异有统计学意义(P＜0.01);③代谢紊乱数量和HOMA-IR均与UAER呈正相关(r=0.976,P＜0.01;r=0.947,P＜0.05).结论代谢紊乱患者UAER和MAU阳性率升高,其原因可能与胰岛素抵抗等因素有关.
목적 탐토미량백단백뇨(MAU)여대사문란적관계.방법 장250례인선환자근거대사문란수량진행분조,검측각조환자적뇨백단백배설솔(UAER)병계산MAU적양성솔,대비각조UAER화MAU양성솔지간적차이.결과 ①대사종합정조환자적체질량지수、요위、수축압、서장압、공복혈당、이도소저항지수(HOMA-IR)、UAER、MAU적양성솔、삼선감유화고민C반응단백균고우대조조,고밀도지단백담고순수평저우대조조(P＜0.01);②수착대사문란수량적증가UAER、MAU양성솔화HOMA-IR균진행성승고(P＜0.05,P＜0.01);1항급이하대사이상환자여2항급이상대사이상환자지간적MAU양성솔차이유통계학의의(P＜0.01);③대사문란수량화HOMA-IR균여UAER정정상관(r=0.976,P＜0.01;r=0.947,P＜0.05).결론 대사문란환자UAER화MAU양성솔승고,기원인가능여이도소저항등인소유관.
Objective To investigate the relationship between microalbuminuria and metabolic disorder. Methods Urinary albumin excretion rate(UAER) were measured in 250 cases. Patients were divided into groups according to the number of metabolic disorders to compare the UAER and positive rate of microalbuminuria in different groups. Results ① Compared with negative controls, patients with metabolic syndrome had higher levels of body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, homeostasis model assessment-insulin resistance index (HOMA-IR) , UAER, positive rate of microalbuminuria, triglyceride and high sensitivity C-reactive protein;and lower levels of high density lipoprotein cholesterol(P＜0.01); ②With the number of metabolic disorders increased, the positive rate of microalbuminuria,UAER and HOMA-IR increased gradually (P＜0.05,P＜0.01), There were much more patients in the group which have two or more metabolic disorders suffered from microalbuminuria than those in group which have one or none metabolic disorder(P＜0.01);③Pearson analysis showed that the number of metabolic disorders and HOMA-IR both were positively correlated with UAER (r=0.976 P＜0.01; r=0.947 P ＜0.05). Conclusion Patients with metabolic disorder had higher levels of UAER and positive rate of microalbuminuria. Maybe it is due to insulin resistance.