中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2010年
2期
115-118
,共4页
溶血磷脂素类%基质金属蛋白酶9%颈动脉狭窄%脑梗塞
溶血燐脂素類%基質金屬蛋白酶9%頸動脈狹窄%腦梗塞
용혈린지소류%기질금속단백매9%경동맥협착%뇌경새
Lysophospholipids%Matrix metalloproteinase 9%Carotid Stenosis%Brain infarction
目的 探讨脑梗死患者血浆溶血磷脂酸(lysophosphatidic acid,LPA)及基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)水平与颈动脉粥样斑块稳定性的关系.方法 选取87例脑梗死患者,根据颈动脉超声检查结果,分为无斑块组9例、内膜增厚组16例、不稳定性斑块组41例、稳定性斑块组21例.根据经颅多普勒(TCD)微栓子检测结果,分为微栓子检测阳性组27例和阴性组60例.分别用无机磷定量法和酶联免疫吸附法测定血浆LPA和MMP-9水平.结果不稳定性斑块组LPA、MMP-9显著高于其他各组(F=49.98、106.49,均P=0.00),稳定性斑块组、内膜增厚组MMP-9差异无统计学意义,但均高于无斑块组(q=7.04、7.51,均P=0.00),稳定性斑块组LPA高于内膜增厚组(q=7.37,P=0.00),并且两组均高于无斑块组(q=8.85,P=0.00;q=2.61,P=0.04).微栓子阳性组血浆LPA、MMP-9水平均显著高于微栓子阴性组(t=42.57、16.61,均P=0.00).LPA与MMP-9水平呈正相关(r=0.22,P=0.032). 结论 LPA与MMP-9参与了脑梗死的病理生理过程,其与颈动脉斑块不稳定性密切相关.
目的 探討腦梗死患者血漿溶血燐脂痠(lysophosphatidic acid,LPA)及基質金屬蛋白酶-9(matrix metalloproteinase-9,MMP-9)水平與頸動脈粥樣斑塊穩定性的關繫.方法 選取87例腦梗死患者,根據頸動脈超聲檢查結果,分為無斑塊組9例、內膜增厚組16例、不穩定性斑塊組41例、穩定性斑塊組21例.根據經顱多普勒(TCD)微栓子檢測結果,分為微栓子檢測暘性組27例和陰性組60例.分彆用無機燐定量法和酶聯免疫吸附法測定血漿LPA和MMP-9水平.結果不穩定性斑塊組LPA、MMP-9顯著高于其他各組(F=49.98、106.49,均P=0.00),穩定性斑塊組、內膜增厚組MMP-9差異無統計學意義,但均高于無斑塊組(q=7.04、7.51,均P=0.00),穩定性斑塊組LPA高于內膜增厚組(q=7.37,P=0.00),併且兩組均高于無斑塊組(q=8.85,P=0.00;q=2.61,P=0.04).微栓子暘性組血漿LPA、MMP-9水平均顯著高于微栓子陰性組(t=42.57、16.61,均P=0.00).LPA與MMP-9水平呈正相關(r=0.22,P=0.032). 結論 LPA與MMP-9參與瞭腦梗死的病理生理過程,其與頸動脈斑塊不穩定性密切相關.
목적 탐토뇌경사환자혈장용혈린지산(lysophosphatidic acid,LPA)급기질금속단백매-9(matrix metalloproteinase-9,MMP-9)수평여경동맥죽양반괴은정성적관계.방법 선취87례뇌경사환자,근거경동맥초성검사결과,분위무반괴조9례、내막증후조16례、불은정성반괴조41례、은정성반괴조21례.근거경로다보륵(TCD)미전자검측결과,분위미전자검측양성조27례화음성조60례.분별용무궤린정량법화매련면역흡부법측정혈장LPA화MMP-9수평.결과불은정성반괴조LPA、MMP-9현저고우기타각조(F=49.98、106.49,균P=0.00),은정성반괴조、내막증후조MMP-9차이무통계학의의,단균고우무반괴조(q=7.04、7.51,균P=0.00),은정성반괴조LPA고우내막증후조(q=7.37,P=0.00),병차량조균고우무반괴조(q=8.85,P=0.00;q=2.61,P=0.04).미전자양성조혈장LPA、MMP-9수평균현저고우미전자음성조(t=42.57、16.61,균P=0.00).LPA여MMP-9수평정정상관(r=0.22,P=0.032). 결론 LPA여MMP-9삼여료뇌경사적병리생리과정,기여경동맥반괴불은정성밀절상관.
Objective To investigate the correlation of plasma lysophosphatidic acid (LPA) and matrix metalloproteinase-9 (MMP-9) with carotid atheromatous plaque stability in patients with cerebral infarction. Methods The duplex uhrasonography and transcranial Doppler-detected microemboli were performed in the carotid arteries of all the 87 patients with cerebral infarction located in arteriae carotis interna system. The patients were divided into the intima thickening group (n=16),unstable plaque group (n=41), stable plaque group (n=21) and non-plaque group (n=9). And there were 27 patients with positive microembolic signal and 60 patients with negative microembolic signal.The plasma levels of LPA and MMP-9 were determined by quantitative determination of inorganic phosphorus and enzyme-linked immunosorbent assay. Results The levels of LPA and MMP-9 were significantly higher in unstable plaque group than in the other three groups (F=49.98 and 106.49,both P<0.01), MMP-9 in intima thickening group and stable plaque group were both higher than in non-plaque group (q=7.04 and 7.51, both P=0. 00). LPA was higher in intima thickening group than in stable plaque group (q=7.37, P=0. 00), and higher in the above two groups than in non-plaque group (both P<0.05). The levels of LPA and MMP-9 were higher in microembolic signal-positive patients than in signal-negative patients (t=42.57 and 16.61, both P=0.00). LPA level was positively correlated with MMP-9 (r=0.22, P<0.05). Conclusions LPA and MMP-9 may serve as a potential risk signal to hint the formation and rupture of unstable carotid atheromatous plaque which may cause ischemic cerebrovascular disease.
