中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
36期
1-3
,共3页
潘军%胡江%谢集建%李涛
潘軍%鬍江%謝集建%李濤
반군%호강%사집건%리도
苯巴比妥%婴儿,新生%缺氧缺血%脑
苯巴比妥%嬰兒,新生%缺氧缺血%腦
분파비타%영인,신생%결양결혈%뇌
Phenobarbital%Infant,newborn%Hypoxia-ischemia%brain
目的 探讨负荷量苯巴比妥在治疗新生儿缺氧缺血性脑病中的作用.方法 将356例新生儿缺氧缺血性脑病患儿按机械抽样法随机分为观察组和对照组,每组178例.两组均给予综合治疗,观察组无论有无惊厥早期应用负荷量苯巴比妥20 m/kg肌肉注射,12h后给维持量5mg/(kg·d)；对照组则在出现神经系统症状时,应用常规剂量苯巴比妥5mg/(kg·d).观察两组的短期疗效和长期疗效.结果 观察组患儿惊厥发生率为11.2％(20/178),对照组患儿为68.0％(121/178),两组比较差异有统计学意义(x2=6.403,P＜0.05)；观察组患儿黄疸发生率为7.9％(14/178),对照组患儿为50.6％(90/178),两组比较差异有统计学意义(x2=78.459,P＜ 0.05).观察组患儿总有效率为87.1％(155/178),对照组患儿为77.5％(138/178),两组比较差异有统计学意义(x2=8.308,P＜0.05).观察组患儿在各月龄时所测得的DQ评分明显高于对照组患儿,差异有统计学意义(P＜0.05).两组患儿均随访至18月龄,观察组神经系统后遗症发生率为7.9％(14/178),对照组患儿为28.1％(50/178),两组比较差异有统计学意义(x2=29.085,P＜ 0.05).结论 负荷量苯巴比妥治疗新生儿缺氧缺血性脑病,可控制惊厥的发生并保护神经系统.
目的 探討負荷量苯巴比妥在治療新生兒缺氧缺血性腦病中的作用.方法 將356例新生兒缺氧缺血性腦病患兒按機械抽樣法隨機分為觀察組和對照組,每組178例.兩組均給予綜閤治療,觀察組無論有無驚厥早期應用負荷量苯巴比妥20 m/kg肌肉註射,12h後給維持量5mg/(kg·d)；對照組則在齣現神經繫統癥狀時,應用常規劑量苯巴比妥5mg/(kg·d).觀察兩組的短期療效和長期療效.結果 觀察組患兒驚厥髮生率為11.2％(20/178),對照組患兒為68.0％(121/178),兩組比較差異有統計學意義(x2=6.403,P＜0.05)；觀察組患兒黃疸髮生率為7.9％(14/178),對照組患兒為50.6％(90/178),兩組比較差異有統計學意義(x2=78.459,P＜ 0.05).觀察組患兒總有效率為87.1％(155/178),對照組患兒為77.5％(138/178),兩組比較差異有統計學意義(x2=8.308,P＜0.05).觀察組患兒在各月齡時所測得的DQ評分明顯高于對照組患兒,差異有統計學意義(P＜0.05).兩組患兒均隨訪至18月齡,觀察組神經繫統後遺癥髮生率為7.9％(14/178),對照組患兒為28.1％(50/178),兩組比較差異有統計學意義(x2=29.085,P＜ 0.05).結論 負荷量苯巴比妥治療新生兒缺氧缺血性腦病,可控製驚厥的髮生併保護神經繫統.
목적 탐토부하량분파비타재치료신생인결양결혈성뇌병중적작용.방법 장356례신생인결양결혈성뇌병환인안궤계추양법수궤분위관찰조화대조조,매조178례.량조균급여종합치료,관찰조무론유무량궐조기응용부하량분파비타20 m/kg기육주사,12h후급유지량5mg/(kg·d)；대조조칙재출현신경계통증상시,응용상규제량분파비타5mg/(kg·d).관찰량조적단기료효화장기료효.결과 관찰조환인량궐발생솔위11.2％(20/178),대조조환인위68.0％(121/178),량조비교차이유통계학의의(x2=6.403,P＜0.05)；관찰조환인황달발생솔위7.9％(14/178),대조조환인위50.6％(90/178),량조비교차이유통계학의의(x2=78.459,P＜ 0.05).관찰조환인총유효솔위87.1％(155/178),대조조환인위77.5％(138/178),량조비교차이유통계학의의(x2=8.308,P＜0.05).관찰조환인재각월령시소측득적DQ평분명현고우대조조환인,차이유통계학의의(P＜0.05).량조환인균수방지18월령,관찰조신경계통후유증발생솔위7.9％(14/178),대조조환인위28.1％(50/178),량조비교차이유통계학의의(x2=29.085,P＜ 0.05).결론 부하량분파비타치료신생인결양결혈성뇌병,가공제량궐적발생병보호신경계통.
Objective To investigate the clinical effect of loading dose of phenobarbital in neonatal hypoxic-ischemic encephalopathy(HIE).Methods Three hundred and fifty-six patients with neonatal HIE were randomly divided into treatment group and control group by systematic sampling,with 178 patients in each group.Two groups were given comprehensive therapy,with or without convalsions,early application of loading dose of phenobarbital in 20 mg/kg intramuscular injection,12 h beck to a maintenance dose 5 mg/(kg·d)in treatment group,while a conventional dose of phenobarbital in 5 mg/(kg·d)was used in control group after convulsion happened.Clinical effect of short-term and long-term were observed.Results The rates of eelampsia,choloplania and total effect was 11.2％(20/178),7.9％(14/178)and 87.1％(155/178)in treatment group,and 68.0％(121/178),50.6％(90/178)and 77.5％(138/178)in control group,there were significant differences between two groups(x2 =6.403,78.459 and 8.308,P ＜ 0.05).DQ score in treatment group was higher than that in control group(P＜ 0.05).The patients in two groups were followed up to age 18 months,the deformity rate in treatment group[7.9％(14/178)]was lower than that in control group[28.1％(50/178)],there was significant difference between two groups(x2 =29.085,P ＜ 0.05).Conclusion Loading dose of phenobarbital is very effective to treat neonatal HIE.
