中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
8期
992-994
,共3页
郭主声%张丽华%林偲思%张丽%朱学海
郭主聲%張麗華%林偲思%張麗%硃學海
곽주성%장려화%림시사%장려%주학해
感染性腹泻%致病菌%抗生素%耐药性
感染性腹瀉%緻病菌%抗生素%耐藥性
감염성복사%치병균%항생소%내약성
Infectious diarrheal%Pathogenic bacteria%Antibiotics%Resistance
目的 探讨东莞部分地区引起感染性腹泻致原菌分布及耐药状况,为本地区流行病学研究及临床合理用药提供依据.方法 收集2001年1月至2009年12月中山大学附属东华医院住院部和门急诊的5939份腹泻患者的粪便标本进行微生物培养、鉴定及药敏试验,并加以比较分析.结果 5939份粪便标本中,共检出致病菌369株,阳性分离率为6.2%,其中分离出志贺菌属118株(32.0%)、沙门菌属115株(31.2%),致病性大肠杆菌81株(21.9%)、弧菌属24株(6.5%)、单胞菌属19株(5.2%)、金黄色葡萄球菌10株(2.7%)及耶氏菌属2株(0.5%).挑选11种抗菌药物进行体外敏感试验,各菌属对抗生素的敏感性有差异,对复方新诺明及氨苄西林耐药率较高,但对第三代头孢有较强的敏感性.结论 东莞地区感染性腹泻的致病菌种类多,且耐药性不同,主要以志贺菌属和沙门菌属为主,应根据微生物鉴定及药敏试验结果指导临床合理使用抗生素,以提高治疗效果.
目的 探討東莞部分地區引起感染性腹瀉緻原菌分佈及耐藥狀況,為本地區流行病學研究及臨床閤理用藥提供依據.方法 收集2001年1月至2009年12月中山大學附屬東華醫院住院部和門急診的5939份腹瀉患者的糞便標本進行微生物培養、鑒定及藥敏試驗,併加以比較分析.結果 5939份糞便標本中,共檢齣緻病菌369株,暘性分離率為6.2%,其中分離齣誌賀菌屬118株(32.0%)、沙門菌屬115株(31.2%),緻病性大腸桿菌81株(21.9%)、弧菌屬24株(6.5%)、單胞菌屬19株(5.2%)、金黃色葡萄毬菌10株(2.7%)及耶氏菌屬2株(0.5%).挑選11種抗菌藥物進行體外敏感試驗,各菌屬對抗生素的敏感性有差異,對複方新諾明及氨芐西林耐藥率較高,但對第三代頭孢有較彊的敏感性.結論 東莞地區感染性腹瀉的緻病菌種類多,且耐藥性不同,主要以誌賀菌屬和沙門菌屬為主,應根據微生物鑒定及藥敏試驗結果指導臨床閤理使用抗生素,以提高治療效果.
목적 탐토동완부분지구인기감염성복사치원균분포급내약상황,위본지구류행병학연구급림상합리용약제공의거.방법 수집2001년1월지2009년12월중산대학부속동화의원주원부화문급진적5939빈복사환자적분편표본진행미생물배양、감정급약민시험,병가이비교분석.결과 5939빈분편표본중,공검출치병균369주,양성분리솔위6.2%,기중분리출지하균속118주(32.0%)、사문균속115주(31.2%),치병성대장간균81주(21.9%)、호균속24주(6.5%)、단포균속19주(5.2%)、금황색포도구균10주(2.7%)급야씨균속2주(0.5%).도선11충항균약물진행체외민감시험,각균속대항생소적민감성유차이,대복방신낙명급안변서림내약솔교고,단대제삼대두포유교강적민감성.결론 동완지구감염성복사적치병균충류다,차내약성불동,주요이지하균속화사문균속위주,응근거미생물감정급약민시험결과지도림상합리사용항생소,이제고치료효과.
Objective To investigate the consitutes and resistance of bacterial pathogens isolated from diarrheal patients in Dongguan area,and to offer the data for guiding epidemiological study and clinical treatment.Methods A total of 5939 stool samples were collected from inpatient department and outpatients in Dongguan hospital between 1st January 2001 and 31 st December 2009.They underwent bacteriological culture,identification,antibiotic sensitive test,and comparative analysis.Results In 5939 cases of patients with diarrhea stool samples,a total of 369 was detected and the positive isdootion rate was 6.2%.The percentage of Shigella,Salmonella,enteropathogenic E.coli,Vibrio,Pseudoalteromonas,Staphylococcus aureus and Yersinia isolated from these 369 samples was 31.9%,31.2% and 21.9%,6.5%,5.2%,2.7% and 0.5%.The sensitivity test of 12 antibavterial drugs were calculated and showed a high rate of drug-resistance to SXT and AMP,but they were susceptible to the third Cephems.Conclusions There are many species and serotype of pathogenic bacteria causing the infective diarrhea in the part of Dongguan area.Shigella and Salmonella are the main causes with a different rate of drug resistance.Antibiotic should be used reasonably with the susceptibility of the pathogen to improve the clinical therapeutic effect.