中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2009年
12期
1213-1216
,共4页
Stathmin%CD105%血管内皮细胞%神经胶质瘤
Stathmin%CD105%血管內皮細胞%神經膠質瘤
Stathmin%CD105%혈관내피세포%신경효질류
Stathmin%CD105%Vascular endothelial cells%Glioma
目的 观察Stathmin及CD105在脑胶质瘤血管内皮细胞中的表达,探讨其在脑胶质瘤血管形成中的作用. 方法 用SP免疫组化法检测10例正常脑组织和78例脑胶质瘤血管内皮细胞中Stathmin和CD105蛋白表达,并通过检测肿瘤微血管密度(MVD)分析肿瘤血管形成.结果 正常脑组织血管内皮细胞中Stathmin和CD105均无表达,脑胶质瘤血管内皮细胞中二者均呈高表达;随着胶质瘤病理级别的增高,Stathmin和CD105表达上调,MVD值增高,Stathmin-MVD和CD105-MVD与脑胶质瘤病理分级均成正相关(r=0.912,P<0.05;P<0.936,P<0.05);且Stathmin-MVD和CD105-MVD之间也存在正相关(r=0.996,P<0.05). 结论 Stathmin与CD105在脑胶质瘤血管内皮细胞中均呈高表达,在肿瘤微血管形成过程起重要作用.
目的 觀察Stathmin及CD105在腦膠質瘤血管內皮細胞中的錶達,探討其在腦膠質瘤血管形成中的作用. 方法 用SP免疫組化法檢測10例正常腦組織和78例腦膠質瘤血管內皮細胞中Stathmin和CD105蛋白錶達,併通過檢測腫瘤微血管密度(MVD)分析腫瘤血管形成.結果 正常腦組織血管內皮細胞中Stathmin和CD105均無錶達,腦膠質瘤血管內皮細胞中二者均呈高錶達;隨著膠質瘤病理級彆的增高,Stathmin和CD105錶達上調,MVD值增高,Stathmin-MVD和CD105-MVD與腦膠質瘤病理分級均成正相關(r=0.912,P<0.05;P<0.936,P<0.05);且Stathmin-MVD和CD105-MVD之間也存在正相關(r=0.996,P<0.05). 結論 Stathmin與CD105在腦膠質瘤血管內皮細胞中均呈高錶達,在腫瘤微血管形成過程起重要作用.
목적 관찰Stathmin급CD105재뇌효질류혈관내피세포중적표체,탐토기재뇌효질류혈관형성중적작용. 방법 용SP면역조화법검측10례정상뇌조직화78례뇌효질류혈관내피세포중Stathmin화CD105단백표체,병통과검측종류미혈관밀도(MVD)분석종류혈관형성.결과 정상뇌조직혈관내피세포중Stathmin화CD105균무표체,뇌효질류혈관내피세포중이자균정고표체;수착효질류병리급별적증고,Stathmin화CD105표체상조,MVD치증고,Stathmin-MVD화CD105-MVD여뇌효질류병리분급균성정상관(r=0.912,P<0.05;P<0.936,P<0.05);차Stathmin-MVD화CD105-MVD지간야존재정상관(r=0.996,P<0.05). 결론 Stathmin여CD105재뇌효질류혈관내피세포중균정고표체,재종류미혈관형성과정기중요작용.
Objective To observe the expressions of stathmin and CD105 in human glioma vascular endothelial cells and explore their significant roles in glioma angiogenesis. Methods The protein expressions of stathmin and CD 105 in the vascular endothelial cells was examined by SP immunohistochemical staining in 10 normal cerebral tissue samples and 78 cases of glioma. The microvessel density (MVD) was measured to analyze the tumor angiogenesis. Results No expression of statnmin and CD105 was found in the normal human brain tissue; while high expression level of both stathmin and CD 105 was showed in the vascular endothelial cells of glioma. The expression level of stathmin and CD 105 and the value of MVD increased following the rise of the pathological grades of glioma; significant linear correlation was showed between the values of stathmin-MVD and CD105-MVD and the pathological grades of the glioma (r=0.912, P<0.05; r=0.936, P<0.05); stathmin-MVD and CD 105-MVD were also positively correlative (r=0.996, P<0.05). Conclusion The Stathmin and CD 105 is highly expressed in the vascular endothelial cells of human glioma, suggesting its important role in the tumor angiogenesis.
