CAJ | 학술논문

[目的]探讨丹参复方液对高血压性肥大心肌L型钙电流的影响.[方法]利用腹主动脉缩窄法建立高血压性心肌肥大模型,利用灌胃法给予丹参复方液,采用离体大鼠心脏Langendorff灌注法急性分离心肌细胞,利用膜片钳全细胞技术记录L型钙电流,比较正常对照组、高血压未治疗组和丹参复方液组之间的区别.[结果]高血压未治疗组的L型钙电流密度显著高于正常对照组(P<0.05),丹参复方液组显著小于高血压未治疗组(P<0.05),丹参复方液组与正常对照组相比无显著性差异(P>0.05).[结论]丹参复方液具有逆转高血压性肥大心肌L型钙电流的药理作用.
[목적]탐토단삼복방액대고혈압성비대심기L형개전류적영향.[방법]이용복주동맥축착법건립고혈압성심기비대모형,이용관위법급여단삼복방액,채용리체대서심장Langendorff관주법급성분리심기세포,이용막편겸전세포기술기록L형개전류,비교정상대조조、고혈압미치료조화단삼복방액조지간적구별.[결과]고혈압미치료조적L형개전류밀도현저고우정상대조조(P<0.05),단삼복방액조현저소우고혈압미치료조(P<0.05),단삼복방액조여정상대조조상비무현저성차이(P>0.05).[결론]단삼복방액구유역전고혈압성비대심기L형개전류적약리작용.
[Objective] To observe the effect of Salvia miltiorrhiza SM compound liquid on cardiocyte L-type calcium channel of cardiac hypertrophy induced by hypertension. [Methods] Cardiac hypertrophy models were made by partial hgation abdominal aortic. SM compound liquid was given by intragastric administration. Langendorff system was used to dissociate single ventricular cell. The current of L-type calcium channels was recorded by whole-cell patch clamp recording technique and compared with control group, hypertension without therapy group and SM compound liquid group. [Re-sults] The current density of L-type calcium channels of hypertension without therapy group was higher than that of con-trol group significantly(P<0.05). The current density of L-type calcium channels of SM compound liquid group was low-er than that of hypertension without therapy group significantly (P<0.05) . There was no significant difference between control group and SM compound liquid group (P>0.05) . [Conclusions] SM compound liquid can reverse cardiocyte L type calcium channel of cardiac hypertrophy induced by hypertension.