中国医药工业杂志
中國醫藥工業雜誌
중국의약공업잡지
CHINESE JOURNAL OF PHARMACEUTICALS
2009年
8期
622-627
,共6页
吸入气雾剂%氟利昂%氢氟烷烃%替代技术挑战%工业化生产
吸入氣霧劑%氟利昂%氫氟烷烴%替代技術挑戰%工業化生產
흡입기무제%불리앙%경불완경%체대기술도전%공업화생산
metered dose inhalers%chlorofluorocarbon%hydrofluoroalkane%propellant replacement challenge%industrial manufacture
吸入气雾剂(MDIs)中抛射剂氟利昂(CFC)的替代并非制剂中简单的辅料替换.综述了氢氟烷烃(HFA)替代CFC过程中所涉及的处方组成改变、工艺参数优化、给药装置的选择、制药设备的更新以及产业化过程中的特殊要求.
吸入氣霧劑(MDIs)中拋射劑氟利昂(CFC)的替代併非製劑中簡單的輔料替換.綜述瞭氫氟烷烴(HFA)替代CFC過程中所涉及的處方組成改變、工藝參數優化、給藥裝置的選擇、製藥設備的更新以及產業化過程中的特殊要求.
흡입기무제(MDIs)중포사제불리앙(CFC)적체대병비제제중간단적보료체환.종술료경불완경(HFA)체대CFC과정중소섭급적처방조성개변、공예삼수우화、급약장치적선택、제약설비적경신이급산업화과정중적특수요구.
The propellant transition in metered dose inhalers (MDIs) is not a simple replacement of CFC by HFA in the formulations. This paper reviews the technical challenges for the development of alternative propellant MDIsincluding changes of formulation composition, optimization of product process, selection of container closure system,improvement of manufacture equipment, and requirements for industrial manufacture.
