CAJ | 학술논문

目的:分析线状皮肤型红斑狼疮的临床表现、组织病理及免疫组化组织病理特点.方法:采用回顾性分析方法对7例线状皮肤型红斑狼绝患者的临床表现、组织病理改变、免疫荧光及实验窀检查资料进行分析.结果:7例患者中男2例,女5例;平均年龄23岁(4～40岁);平均发病年龄19.43岁(3～37岁),其中2例发病年龄<6岁.皮损部位:1例位于左下肢,其余6例均位于头面部.皮损均呈线状分布,其走向与Blasehko线一致;所有患者均无系统受累的证据.结合组织病理和免疫荧光检查,6例诊断为线状盘状红斑狼疮,1例为线状深在性红斑狼疮.结论:线状皮肤型红斑狼疮是红斑狼疮的罕见变异型,不引起系统受累.临床诊断有一定困难,需借助于组织病理和免疫荧光检查.
목적:분석선상피부형홍반랑창적림상표현、조직병리급면역조화조직병리특점.방법:채용회고성분석방법대7례선상피부형홍반랑절환자적림상표현、조직병리개변、면역형광급실험둔검사자료진행분석.결과:7례환자중남2례,녀5례;평균년령23세(4～40세);평균발병년령19.43세(3～37세),기중2례발병년령<6세.피손부위:1례위우좌하지,기여6례균위우두면부.피손균정선상분포,기주향여Blasehko선일치;소유환자균무계통수루적증거.결합조직병리화면역형광검사,6례진단위선상반상홍반랑창,1례위선상심재성홍반랑창.결론:선상피부형홍반랑창시홍반랑창적한견변이형,불인기계통수루.림상진단유일정곤난,수차조우조직병리화면역형광검사.
Objective:To analyze the clinical,histopathologic and immunopathologic characteristics of linear cutaneous lupus erythematosus.Methods:The clinical,histopathologic,immunopathologic characteristics and laboratory examinations of 7 pa-tients with linear cutaneous lupus erythematosus were analyzed retrospectively. Results:The mean age of all cases(2 men and 5 women)was 23 years with a range from 4 to 40 years.At the onset,2 of 7 patients were under the age of 6 years,with a mean age of 19.43 years(ranging from 3 to 37 years).One patient had lesions on the left lower extremity,and six on the face and head.All patients showed a linear lesion along the lines of Blaschko,No systemic involvement has been recog-nized.Six patients were diagnosed as linear discoid lupus erythematosus,another was linear lupus erythematosus profundus,according to the clinical,histopathologic and immunopathologic features.Conclusions:Linear cutaneous lupus erythematosusis a rare variant of lupus erythematosus.No systemic involvement was documented.The clinical diagnosis of linear cutaneous lupus erythematosus may be difficult.The histopathologic and immunopathologic features are helpful to confirm the diagnosis.