CAJ | 학술논문

Notch信号通路参与多种组织细胞的分化成熟过程,尤其在外周T细胞的分化过程中起了决定性的作用,参与多种过敏性疾病(如支气管哮喘)的发生发展.近来研究表明Notch信号通路还参与诱发支气管哮喘的气道高反应性和促进气道黏液细胞增生.本文就Notch信号转导通路与支气管哮喘的关系作一综述.
Notch신호통로삼여다충조직세포적분화성숙과정,우기재외주T세포적분화과정중기료결정성적작용,삼여다충과민성질병(여지기관효천)적발생발전.근래연구표명Notch신호통로환삼여유발지기관효천적기도고반응성화촉진기도점액세포증생.본문취Notch신호전도통로여지기관효천적관계작일종술.
The Notch signaling pathway is involved in cell-differentiation process in a wide variaty tissues, especially playing an essential role in the differentiation of the periphery T lymphocyte. It correlates with the development of many diffenrent allergic diseases, such as bronchial asthma. Recently, many reports have demonstrated that the Notch signaling pathway also plays an important role in inducing the airway hyper-responsiveness of asthma, as well as promotes the metaplasia of the airway mucilage cell. In this review, we highlight the relationship between Notch signaling pathway and bronchial asthma.