CAJ | 학술논문

目的探讨胎球蛋白A(Fetuin-A)对腹膜透析患者的颈动脉粥样硬化及心血管事件的影响.方法对30例腹膜透析患者进行血浆Fetuin-A及相关因素检测,所有患者均接受颈动脉斑块超声检测,并随访12个月.10例正常人列入对照组.结果 ESRD患者中,Fetuin-A浓度高的患者心血管事件发生率低于Fetuin-A浓度低的患者,logistic同归分析显示ESRD患者的心血管事件与Fetuin-A及颈动脉粥样硬化密切相关.在进行腹膜透析随访的12个月内,Fetuin-A 浓度高的患者颈动脉粥样硬化及新发心血管事件明显低于Fetuin-A浓度低的患者.结论 Fetuin-A与ESRD透析患者的颈动脉硬化及心血管事件关系密切,Fetuin-A水平下降是ESRD患者心血管事件发生的危险因素.
목적 탐토태구단백A(Fetuin-A)대복막투석환자적경동맥죽양경화급심혈관사건적영향.방법 대30례복막투석환자진행혈장Fetuin-A급상관인소검측,소유환자균접수경동맥반괴초성검측,병수방12개월.10례정상인렬입대조조.결과 ESRD환자중,Fetuin-A농도고적환자심혈관사건발생솔저우Fetuin-A농도저적환자,logistic동귀분석현시ESRD환자적심혈관사건여Fetuin-A급경동맥죽양경화밀절상관.재진행복막투석수방적12개월내,Fetuin-A 농도고적환자경동맥죽양경화급신발심혈관사건명현저우Fetuin-A농도저적환자.결론 Fetuin-A여ESRD투석환자적경동맥경화급심혈관사건관계밀절,Fetuin-A수평하강시ESRD환자심혈관사건발생적위험인소.
Objective To explore the impacts of serum fetuin-A on carotid plaques and cardiovescular events in peritoneal-dialysis patients. Methords Serum fetuin-A and related factors were detected in thirty peritoneal-dialysis patients, so was carotid intima-media thickness (cIMT)by ultrasonography.All the patients were followed up for 12 months. 10 normal people were enrolled in the control group. Results The incidence of cardiovascular events was lower in patients with higher fetuin-A levels than those with lower levels. Logistic regression analysis indicated that serum fetuin-A and carotid plaques were closely associated with cardiovescular events; During 12-month follow-up, carotid plaques and the incidence of cardiovescular events were lower in patients with high serum fetuin-A levels. Conclusions Serum fetuin-A is correlated with carotid plaques and cardiovescular events in peritoneal dialysis patients. A decrease in fetuin-A is a risk factor for cardiovascular events in ESRD patients.