中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2009年
1期
24-26
,共3页
睡眠呼吸暂停,阻塞性%嗜睡%肿瘤坏死因子α%微觉醒指数
睡眠呼吸暫停,阻塞性%嗜睡%腫瘤壞死因子α%微覺醒指數
수면호흡잠정,조새성%기수%종류배사인자α%미각성지수
Sleep apnea,obstructive%Lethargy%Tumor necrosis factor-alpha%Microarousal index
目的 探讨阻塞型睡眠呼吸暂停低通气综合征(OSAHS)患者日间嗜睡、TNF-α水平及微觉醒的关系.方法 选取多导睡眠图证实为OSAHS的男性患者40例(OSAHS组),另选择经多导睡眠图检查无OSAHS的健康者15例作为对照组.测定两组受检者血清中TNF-α水平,以Epworth嗜睡量表进行问卷调查并判断嗜睡评分.结果 OSAHS组血清TNF-α水平[(18.42±6.23)ng/L]较对照组[(9.75±3.12)ng/L]明显升高(P＜0.01),两组的嗜睡评分、微觉醒指数比较差异有统计学意义.OSAHS组血清TNF-α水平与微觉醒指数、嗜睡评分呈正相关(r值分别为0.373、0.461,P＜0.01),嗜睡评分与呼吸暂停低通气指数、微觉醒指数呈正相关(r值分别为0.443、0.751,P＜0.01).结论 OSAHS患者嗜睡评分、TNF-α、微觉醒指数升高.OSAHS相关的微觉醒对日间嗜睡的发生起了重要作用,TNF-α水平异常可能是造成睡眠呼吸紊乱的主要原因之一.
目的 探討阻塞型睡眠呼吸暫停低通氣綜閤徵(OSAHS)患者日間嗜睡、TNF-α水平及微覺醒的關繫.方法 選取多導睡眠圖證實為OSAHS的男性患者40例(OSAHS組),另選擇經多導睡眠圖檢查無OSAHS的健康者15例作為對照組.測定兩組受檢者血清中TNF-α水平,以Epworth嗜睡量錶進行問捲調查併判斷嗜睡評分.結果 OSAHS組血清TNF-α水平[(18.42±6.23)ng/L]較對照組[(9.75±3.12)ng/L]明顯升高(P＜0.01),兩組的嗜睡評分、微覺醒指數比較差異有統計學意義.OSAHS組血清TNF-α水平與微覺醒指數、嗜睡評分呈正相關(r值分彆為0.373、0.461,P＜0.01),嗜睡評分與呼吸暫停低通氣指數、微覺醒指數呈正相關(r值分彆為0.443、0.751,P＜0.01).結論 OSAHS患者嗜睡評分、TNF-α、微覺醒指數升高.OSAHS相關的微覺醒對日間嗜睡的髮生起瞭重要作用,TNF-α水平異常可能是造成睡眠呼吸紊亂的主要原因之一.
목적 탐토조새형수면호흡잠정저통기종합정(OSAHS)환자일간기수、TNF-α수평급미각성적관계.방법 선취다도수면도증실위OSAHS적남성환자40례(OSAHS조),령선택경다도수면도검사무OSAHS적건강자15례작위대조조.측정량조수검자혈청중TNF-α수평,이Epworth기수량표진행문권조사병판단기수평분.결과 OSAHS조혈청TNF-α수평[(18.42±6.23)ng/L]교대조조[(9.75±3.12)ng/L]명현승고(P＜0.01),량조적기수평분、미각성지수비교차이유통계학의의.OSAHS조혈청TNF-α수평여미각성지수、기수평분정정상관(r치분별위0.373、0.461,P＜0.01),기수평분여호흡잠정저통기지수、미각성지수정정상관(r치분별위0.443、0.751,P＜0.01).결론 OSAHS환자기수평분、TNF-α、미각성지수승고.OSAHS상관적미각성대일간기수적발생기료중요작용,TNF-α수평이상가능시조성수면호흡문란적주요원인지일.
Objective To investigate the association among daytime sleepiness,serum tumor necrosis factor(TNF)-α levels and microarousal in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods Forty male patients with OSAHS conformed by apnea hypopnea index(AHI)during sleep monitoring of polysomnography were selected as OSAHS group,15 healthy subjects were selected as control group.The level of serum TNF-α was measured by ELISA.The Epworth sleepiness(EP)scale was used in two groups.Results The level of serum TNF-α in OSAHS group[(18.42±6.23)ng/L]was significantly higher than that in control group[(9.75±3.12)ng/L],P＜0.01.The EP scale and micmarousal index were signifieand yhigher in OSAHS group than those in control group[(16.9±4.7)acores vs(4.5±2.3)dcores,(33.6±16.9)times/h vs(11.3±7.3)times/h,P＜0.01].The EP scale in OSAHS group was positively correlated with the levels of serum TNF-α(r=0.461,P＜0.01),AHI(r=0.443,P＜0.01)and microarousal index(r=0.751,P＜0.01)respectively.The levels of serum'INF-α in patients with OSAHS were also positively correlated with microarousal index(r=0.373,P＜0.01).Conclusions The levels of serum TNF-α and mieroarousal index are increased in patients with 0SAHS.The microarousal related to OSAHS plays an important role on the daytime sleepiness,the unusual levels of serum TNF-α maybe lead to interferen of sleepiness.
