中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2012年
10期
675-678
,共4页
张明帅%张国庆%甫拉提·吾瓦力汉%朱丽萍%倪多
張明帥%張國慶%甫拉提·吾瓦力漢%硃麗萍%倪多
장명수%장국경%보랍제·오와력한%주려평%예다
乳腺肿瘤%肿瘤转移%腋窝淋巴结%维吾尔族%Logistic回归
乳腺腫瘤%腫瘤轉移%腋窩淋巴結%維吾爾族%Logistic迴歸
유선종류%종류전이%액와림파결%유오이족%Logistic회귀
Breast neoplasms%Neoplasm metastasis%Axillary lymph node%Uygur nationality%Logistic regression model
目的 对比分析影响新疆维、汉族女性乳腺癌患者腋窝淋巴结转移的危险因素.方法 对309例汉族和维吾尔族临床诊断为T1期乳腺癌患者的完整临床资料进行回顾性分析,并对影响腋窝淋巴结转移的危险因素进行单因素及多因素[包括民族、年龄、月经状态、妊娠次数、产次、肿瘤部位、病理类型、雌激素受体(ER)、Ki-67等]Logistic回归分析.结果 T1期维、汉族女性乳腺癌腋窝淋巴结转移率分别为43.9％、30.9％,其中腋窝淋巴结转移1～3个者维吾尔族组17例(25.8％),汉族组52例(21.4％),腋窝淋巴结转移≥4个者维吾尔族组12例(18.2％),汉族组23例(9.5％)；Ki-67表达维吾尔族组为62.1％ (41/66)汉族组为75.3％ (183/243),两组比较差异均有统计学意义(均P ＜0.05)；T1期维、汉族女性在妊娠次数、产次两组比较差异有统计学意义(P＜0.05)；多因素Logistic回归分析结果显示,年龄、妊娠次数、肿瘤所在象限是预测维、汉民族乳腺癌患者腋窝淋巴结转移的危险因素,而ER阳性表达是保护因素.结论 T1期维吾尔族乳腺癌患者腋窝淋巴结转移率高于汉族乳腺癌患者；年龄较轻、妊娠次数较多、肿瘤所在象限位于外侧象限及乳晕区者易发生腋窝淋巴结的转移,ER阳性表达可能抑制淋巴结转移.
目的 對比分析影響新疆維、漢族女性乳腺癌患者腋窩淋巴結轉移的危險因素.方法 對309例漢族和維吾爾族臨床診斷為T1期乳腺癌患者的完整臨床資料進行迴顧性分析,併對影響腋窩淋巴結轉移的危險因素進行單因素及多因素[包括民族、年齡、月經狀態、妊娠次數、產次、腫瘤部位、病理類型、雌激素受體(ER)、Ki-67等]Logistic迴歸分析.結果 T1期維、漢族女性乳腺癌腋窩淋巴結轉移率分彆為43.9％、30.9％,其中腋窩淋巴結轉移1～3箇者維吾爾族組17例(25.8％),漢族組52例(21.4％),腋窩淋巴結轉移≥4箇者維吾爾族組12例(18.2％),漢族組23例(9.5％)；Ki-67錶達維吾爾族組為62.1％ (41/66)漢族組為75.3％ (183/243),兩組比較差異均有統計學意義(均P ＜0.05)；T1期維、漢族女性在妊娠次數、產次兩組比較差異有統計學意義(P＜0.05)；多因素Logistic迴歸分析結果顯示,年齡、妊娠次數、腫瘤所在象限是預測維、漢民族乳腺癌患者腋窩淋巴結轉移的危險因素,而ER暘性錶達是保護因素.結論 T1期維吾爾族乳腺癌患者腋窩淋巴結轉移率高于漢族乳腺癌患者；年齡較輕、妊娠次數較多、腫瘤所在象限位于外側象限及乳暈區者易髮生腋窩淋巴結的轉移,ER暘性錶達可能抑製淋巴結轉移.
목적 대비분석영향신강유、한족녀성유선암환자액와림파결전이적위험인소.방법 대309례한족화유오이족림상진단위T1기유선암환자적완정림상자료진행회고성분석,병대영향액와림파결전이적위험인소진행단인소급다인소[포괄민족、년령、월경상태、임신차수、산차、종류부위、병리류형、자격소수체(ER)、Ki-67등]Logistic회귀분석.결과 T1기유、한족녀성유선암액와림파결전이솔분별위43.9％、30.9％,기중액와림파결전이1～3개자유오이족조17례(25.8％),한족조52례(21.4％),액와림파결전이≥4개자유오이족조12례(18.2％),한족조23례(9.5％)；Ki-67표체유오이족조위62.1％ (41/66)한족조위75.3％ (183/243),량조비교차이균유통계학의의(균P ＜0.05)；T1기유、한족녀성재임신차수、산차량조비교차이유통계학의의(P＜0.05)；다인소Logistic회귀분석결과현시,년령、임신차수、종류소재상한시예측유、한민족유선암환자액와림파결전이적위험인소,이ER양성표체시보호인소.결론 T1기유오이족유선암환자액와림파결전이솔고우한족유선암환자；년령교경、임신차수교다、종류소재상한위우외측상한급유훈구자역발생액와림파결적전이,ER양성표체가능억제림파결전이.
Objective To comparatively explore the risk factors of axillary lymph node metastasis (ALNM) in Uygur and Han patients with breast cancer.Methods A total of 243 female Han patients and 66 Uygur ones with T1 stage breast cancer were retrospectively studied by single and multi-factorial Logistic regression analysis.Results The rates of ALNM were 43.94％ and 30.86％ in Uygur and Han patients respectively.There was statistic difference between them.Statistic differences existed between these two nationals in gravidity and parity.Multi-Factorial Logistic regression analysis showed that age,gravidity and quadrant of tumor localized were the risk factors of ALNM while estrogen receptor (ER) ( + ) was the protective factor.Conclusions The rate of ALNM in Uygur patients with T1 stage breast cancer is higher than that in Han counterparts. More gravidity is an influencing factor. Younger age,more gravidity and location of tumor are the high risk factors for ALNM while ER ( + ) is the protective factor.
