中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2010年
4期
286-289
,共4页
结直肠肿瘤%肿瘤转移%预后%外科切除
結直腸腫瘤%腫瘤轉移%預後%外科切除
결직장종류%종류전이%예후%외과절제
Colorectal neoplasms%Neoplasm metastasis%Prognosis%Surgical resection
目的 探讨结直肠癌肝转移患者的生存情况及其预后相关因素.方法 采用Kaplan-Meier和多因素回归分析方法,分析112例有完整随访资料的结直肠癌肝转移患者的生存情况及影响预后的相关因素.结果 112例患者的中位生存时间为18.3个月,1、2、3和5年生存率分别为60.8%、35.0%、20.3%和4.8%.单因素分析显示,患者性别、年龄、原发肿瘤部位、化疗与否、肿瘤的病理类型与患者的总生存时间无关(P＞0.05),而原发肿瘤治疗方法、肝脏转移时间、原发肿瘤大体类型、肝脏转移灶手术与否和临床分期与患者的预后有关(P＜0.05).多因素回归分析显示,肝脏转移灶手术与否、原发肿瘤大体类型和临床分期是影响结直肠癌肝转移患者预后的主要因素(P＜0.05).结论 对于结直肠癌肝转移的患者应积极切除肝转移病灶,延长患者生存时间.
目的 探討結直腸癌肝轉移患者的生存情況及其預後相關因素.方法 採用Kaplan-Meier和多因素迴歸分析方法,分析112例有完整隨訪資料的結直腸癌肝轉移患者的生存情況及影響預後的相關因素.結果 112例患者的中位生存時間為18.3箇月,1、2、3和5年生存率分彆為60.8%、35.0%、20.3%和4.8%.單因素分析顯示,患者性彆、年齡、原髮腫瘤部位、化療與否、腫瘤的病理類型與患者的總生存時間無關(P＞0.05),而原髮腫瘤治療方法、肝髒轉移時間、原髮腫瘤大體類型、肝髒轉移竈手術與否和臨床分期與患者的預後有關(P＜0.05).多因素迴歸分析顯示,肝髒轉移竈手術與否、原髮腫瘤大體類型和臨床分期是影響結直腸癌肝轉移患者預後的主要因素(P＜0.05).結論 對于結直腸癌肝轉移的患者應積極切除肝轉移病竈,延長患者生存時間.
목적 탐토결직장암간전이환자적생존정황급기예후상관인소.방법 채용Kaplan-Meier화다인소회귀분석방법,분석112례유완정수방자료적결직장암간전이환자적생존정황급영향예후적상관인소.결과 112례환자적중위생존시간위18.3개월,1、2、3화5년생존솔분별위60.8%、35.0%、20.3%화4.8%.단인소분석현시,환자성별、년령、원발종류부위、화료여부、종류적병리류형여환자적총생존시간무관(P＞0.05),이원발종류치료방법、간장전이시간、원발종류대체류형、간장전이조수술여부화림상분기여환자적예후유관(P＜0.05).다인소회귀분석현시,간장전이조수술여부、원발종류대체류형화림상분기시영향결직장암간전이환자예후적주요인소(P＜0.05).결론 대우결직장암간전이적환자응적겁절제간전이병조,연장환자생존시간.
Objective To analyze the survival status and prognostic factors of patients with liver metastases from colorectal cancer.Methods The survival rate and prognostic factors of 112 patients with liver metastases from colorectal cancer,who had complete follow-up data,were retrospectively assessed by Kaplan-Meier analysis and multivariate regression analysis.Results The median survival time of the 112 patients was 18.25 months.The 1-,2-,3-and 5-year overall survival rates were 60.8%,35.0%,20.3% and 4.8%,respectively.Univariate analysis demonstrated that gender,age,primary tumor site,chemotherapy and pathological types had no significant correlation with the overall survival.But the treatment of primary tumor,time of liver metastasis,gross type of tumor,resection of liver metastases and clinical stage status were all independently related with the prognosis of patients.Multivariate regression analysis showed that resection of liver metastases,gross type of tumor and clinical stage were key factors affecting the prognosis of patients with liver metastases from colorectal cancer.Conclusion Patients with advanced stage,infiltrative gross type of colorectal cancer should be followed-up closely so that liver metastases from the cancer can be diagnosed and treated early.Resection of both the primary tumor and liver metastasis may improve survival of the patients.
