1,4,7,10-N,N,N,N.四(2-(4-(2-乙酰硫基乙氧基)苯氧基)乙基)-1,4,7,10-四氮杂环十二烷的合成研究
1,4,7,10-N,N,N,N.사(2-(4-(2-을선류기을양기)분양기)을기)-1,4,7,10-사담잡배십이완적합성연구
Synthesis of 1,4,7,10- N, N, N, N-Tetra- (2- (4- (2-acetylthioethoxy) phenoxy) - ethyl)-1,4,7,10-tetraazacyclododecane
  • 万方数据
    化学通报（印刷版） 화학통보（인쇄판）
    CHEMISTRY
    2009年 12期 1132-1135 ,共4页

    鞠生兰%孙小强%付永胜%席海涛

    국생란%손소강%부영성%석해도

    乙酰硫基%cyclen衍生物%合成 乙酰硫基%cyclen衍生物%閤成
    을선류기%cyclen연생물%합성
    Ethanethioate%Cyclen derivative%Synthesis
    以对苄氧基苯酚为原料,经3步反应合成不对称的对苯二酚烷氧基化合物,并以此为原料,合成乙酰硫基修饰的cyclen四取代氢醌醚链化合物.该路线不仅反应条件温和,操作易行,且收率高,克服了文献报道的合成路线重复性差、收率低的缺点.关键中间体及目标化合物经~1H NMR、~(13)C NMR、MS、IR和元素分析表征.
    이대변양기분분위원료,경3보반응합성불대칭적대분이분완양기화합물,병이차위원료,합성을선류기수식적cyclen사취대경곤미련화합물.해로선불부반응조건온화,조작역행,차수솔고,극복료문헌보도적합성로선중복성차、수솔저적결점.관건중간체급목표화합물경~1H NMR、~(13)C NMR、MS、IR화원소분석표정.
    Tided compound was conveniently synthesized from asymmetric hydroquinone alkoxy compound which was prepared from 4-(benzyloxy) phenol after three-step reaction. Compared to reported methods in literatures, this one was more readily performed with much better yields under mild conditions. The key intermediates and the target compound were characterized by ~(1) H NMR, ~(13) C NMR, MS, IB and elemental analysis.
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