CAJ | 학술논문

目的探讨声触诊组织量化(VTQ)技术在甲状腺实性小结节良恶性鉴别诊断中的应用价值.方法选择常规超声难以鉴别良恶性的甲状腺实性单发结节,结节最大径范围5～15 mm,甲状腺实质回声均匀,血供正常的病例,应用VTQ技术测量甲状腺结节及非结节部位各5次,根据剪切波速度(Vs)绘制ROC曲线.结果共62例患者67个病灶入选,其中恶性39个,良性28个.恶性组结节、恶性组非结节部、良性组结节、良性组非结节部Vs分别为(3.91±1.85)m/s、(2.03±0.42)m/s、(2.29±0.56) m/s、(1.84±0.45) m/s.良、恶性结节Vs差异有统计学意义(P=0.000),良、恶性结节的非结节部Vs差异无统计学意义(P=0.07).以2.78 m/s为截断值诊断甲状腺恶性病变的灵敏度、特异度及准确度分别为76.9％、78.6％、80.6％,ROC曲线下面积为0.84.结论 VTQ技术可用于评价甲状腺结节硬度,为判断其良恶性提供一定的诊断依据.
목적 탐토성촉진조직양화(VTQ)기술재갑상선실성소결절량악성감별진단중적응용개치.방법 선택상규초성난이감별량악성적갑상선실성단발결절,결절최대경범위5～15 mm,갑상선실질회성균균,혈공정상적병례,응용VTQ기술측량갑상선결절급비결절부위각5차,근거전절파속도(Vs)회제ROC곡선.결과 공62례환자67개병조입선,기중악성39개,량성28개.악성조결절、악성조비결절부、량성조결절、량성조비결절부Vs분별위(3.91±1.85)m/s、(2.03±0.42)m/s、(2.29±0.56) m/s、(1.84±0.45) m/s.량、악성결절Vs차이유통계학의의(P=0.000),량、악성결절적비결절부Vs차이무통계학의의(P=0.07).이2.78 m/s위절단치진단갑상선악성병변적령민도、특이도급준학도분별위76.9％、78.6％、80.6％,ROC곡선하면적위0.84.결론 VTQ기술가용우평개갑상선결절경도,위판단기량악성제공일정적진단의거.
Objective To explore the application value of virtual touch tissue quantification(VTQ) technique in differentiating small solid thyroid nodules.Methods The patients with suspiciously malignant thyroid nodules(solitary,size range 5-15 mm),homogeneous and normal color Doppler flow imaging in the rest of thyroid parenchyma,were enrolled in this study.Five repeated measurements were performed on both nodules and extra-nodular tissues using VTQ.A receiver-operating characteristic (ROC) curve was drew according to shear wave velocity(Vs).Results 62 patients with a total of 67 lesions were included in this study,turned out to be 39 malignant and 28 benign.The Vs of malignant group nodules,malignant group extra-nodular tissues,benign group nodules and benign group extra-nodular tissues were (3.91 ±1.85) m/s,(2.03 ± 0.42)m/s,(2.29 ± 0.56)m/s,(1.84 ± 0.45)m/s,respectively.The Vs difference between malignant and benign nodules was statistically significant (P =0.000),while the Vs difference between malignant and benign extra-nodular tissues had no statistical significance (P =0.07).The best cutoff Vs value for distinguishing malignant from benign nodules was 2.78 m/s,with the sensitivity,specificity and accuracy of 76.9％,78.6％ and 80.6％ respectively.The area under ROC curve was 0.84.Conclusions VTQ could evaluate the elasticity of thyroid nodules,and was helpful in the diagnostic work-up of thyroid nodules.