中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2012年
2期
146-148
,共3页
童重新%郝淑维%邢小芬%乔书花%刘琳%丁占平
童重新%郝淑維%邢小芬%喬書花%劉琳%丁佔平
동중신%학숙유%형소분%교서화%류림%정점평
早发型重度子痫前期%低分子肝素钙%延长孕龄%围生儿
早髮型重度子癇前期%低分子肝素鈣%延長孕齡%圍生兒
조발형중도자간전기%저분자간소개%연장잉령%위생인
Early onset severe pre-eclampsia%Low molecular heparin calcium%Extended gestational age%Perinatals
目的 观察低分子肝素钙治疗早发型重度子病前期临床疗效.方法 选取孕龄26～34周重度子痫前期患者60例,分为观察组28例和对照组32例,观察组在常规治疗基础上加用低分子肝素钙,对比两组治疗后延长孕龄时间、脐动脉S/D比值、羊水指数、胎盘重量、新生儿体质量及Apgar评分间的差异.结果 平均延长孕龄时间观察组与对照组比较差异有统计学意义[(10.19±4.57)d与(6.14±3.56)d,t=3.872,P＜0.01].脐动脉S/D比值、羊水指数、胎盘重量、新生儿体质量,两组比较差异均有统计学意义(t值分别为9.056、5.259、2.157,2.027;P ＜0.01,＜0.05).1分钟及5分钟新生儿Apgar评分提高,两组比较差异均有统计学意义(x2值分别为8.058、7.190,P均＜0.01).结论 应用低分子肝素钙治疗早发型重度子痫前期可延长孕龄,增加新生儿体质量,有效改善新生儿预后.
目的 觀察低分子肝素鈣治療早髮型重度子病前期臨床療效.方法 選取孕齡26～34週重度子癇前期患者60例,分為觀察組28例和對照組32例,觀察組在常規治療基礎上加用低分子肝素鈣,對比兩組治療後延長孕齡時間、臍動脈S/D比值、羊水指數、胎盤重量、新生兒體質量及Apgar評分間的差異.結果 平均延長孕齡時間觀察組與對照組比較差異有統計學意義[(10.19±4.57)d與(6.14±3.56)d,t=3.872,P＜0.01].臍動脈S/D比值、羊水指數、胎盤重量、新生兒體質量,兩組比較差異均有統計學意義(t值分彆為9.056、5.259、2.157,2.027;P ＜0.01,＜0.05).1分鐘及5分鐘新生兒Apgar評分提高,兩組比較差異均有統計學意義(x2值分彆為8.058、7.190,P均＜0.01).結論 應用低分子肝素鈣治療早髮型重度子癇前期可延長孕齡,增加新生兒體質量,有效改善新生兒預後.
목적 관찰저분자간소개치료조발형중도자병전기림상료효.방법 선취잉령26～34주중도자간전기환자60례,분위관찰조28례화대조조32례,관찰조재상규치료기출상가용저분자간소개,대비량조치료후연장잉령시간、제동맥S/D비치、양수지수、태반중량、신생인체질량급Apgar평분간적차이.결과 평균연장잉령시간관찰조여대조조비교차이유통계학의의[(10.19±4.57)d여(6.14±3.56)d,t=3.872,P＜0.01].제동맥S/D비치、양수지수、태반중량、신생인체질량,량조비교차이균유통계학의의(t치분별위9.056、5.259、2.157,2.027;P ＜0.01,＜0.05).1분종급5분종신생인Apgar평분제고,량조비교차이균유통계학의의(x2치분별위8.058、7.190,P균＜0.01).결론 응용저분자간소개치료조발형중도자간전기가연장잉령,증가신생인체질량,유효개선신생인예후.
Objective To analyze the clinical effects of low molecular heparin calcium on early onset severe pre-eclampsia.Methods Sixty patients with early onset severe pre-eclampsia at 26-34 weeks of gestational age were divided into treatment group(28 cases)and control group(32 cases).The conventional treatment was delivered in control group and low molecalar heparin calcium(LMWHC)was used in treatment group additionally.The time of prolonged gestational age,umbilical arterial S/D ratio,amniotic fluid index,placenta weight,neonatal weight and Apgar score were measured in two groups.Results The time of prolonged gestational age was 10.19 ±4.57days in treatment group and 6.14 ±3.56 days in control group,which were significantly different(P ＜ 0.01).Umbilical arterial S/D ratio,amniotic fluid index,placenta weight and neonatal weight were all significantly different between the two groups(P ＜ 0.05).Neonatal Apgar score in treatment group was remarkably improved(P ＜ 0.01).Conclusion LMWHC treatment in the patients with early onset severe pre-eclampsia could extend gestational age,increase neonatal weight and improve perinatal outcomes.
