国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2012年
3期
177-181
,共5页
抗原,CD40%多态现象,遗传学%卒中%脑缺血%颈动脉疾病%动脉粥样硬化%危险因素
抗原,CD40%多態現象,遺傳學%卒中%腦缺血%頸動脈疾病%動脈粥樣硬化%危險因素
항원,CD40%다태현상,유전학%졸중%뇌결혈%경동맥질병%동맥죽양경화%위험인소
Antigens,CD40%Polymorphism,Genetic%Stroke%Brain Ischemia%Carotid Artery Diseases%Atherosclerosis%Risk Factors
目的 探讨CD40基因启动子区- 1C/T基因多态性与颈动脉粥样硬化斑块和大动脉粥样硬化性卒中的相关性.方法 研究对象为急性大动脉粥样硬化性卒中患者(病例组)和无卒中史的体检者(对照组).病例组进一步分为不稳定斑块亚组、稳定斑块亚组和无斑块亚组.采用聚合酶链反应-限制性片段长度多态性技术检测CD40 - 1C/T基因多态性.结果 共纳入大动脉粥样硬化性卒中患者170例(病例组)和61名无卒中史的体检者(对照组).在病例组中,不稳定斑块亚组51例,稳定斑块亚组60例,无斑块亚组59例.病例组C等位基因频率显著高于对照组(52.9％对38.5％;x2=7.466,P=0.006).在病例组中,不稳定斑块亚组C等位基因频率(75.5％)显著性高于稳定斑块亚组(53.3％),且两者均显著高于无斑块亚组(33.1％)(稳定斑块亚组与无斑块亚组比较:x2 =9.970,P=0.002;不稳定斑块亚组与稳定斑块亚组比较:x2=11.680,P=0.001;不稳定斑块亚组与无斑块亚组比较:x2 =39.532,P=0.000).多变量logistic回归分析显示,高血压(OR9.513,95％ CI1.291 ～20.779;P =0.028)、TC水平增高(OR 4.235,95％ Cl 1.069 ～ 19.034；P=0.032)、LDL水平增高(OR 4.201,95％ CI 1.803 ～9.672；P=0.001)以及携带C等位基因(OR 1.759,95％ CI 1.177～2.738;P =0.006)是大动脉粥样硬化性卒中的独立危险因素.结论 CD40 - 1C/T基因多态性与颈动脉粥样硬化斑块形成、不稳定性以及缺血性卒中风险相关,C等位基因可能为大动脉粥样硬化性卒中的易感因素.
目的 探討CD40基因啟動子區- 1C/T基因多態性與頸動脈粥樣硬化斑塊和大動脈粥樣硬化性卒中的相關性.方法 研究對象為急性大動脈粥樣硬化性卒中患者(病例組)和無卒中史的體檢者(對照組).病例組進一步分為不穩定斑塊亞組、穩定斑塊亞組和無斑塊亞組.採用聚閤酶鏈反應-限製性片段長度多態性技術檢測CD40 - 1C/T基因多態性.結果 共納入大動脈粥樣硬化性卒中患者170例(病例組)和61名無卒中史的體檢者(對照組).在病例組中,不穩定斑塊亞組51例,穩定斑塊亞組60例,無斑塊亞組59例.病例組C等位基因頻率顯著高于對照組(52.9％對38.5％;x2=7.466,P=0.006).在病例組中,不穩定斑塊亞組C等位基因頻率(75.5％)顯著性高于穩定斑塊亞組(53.3％),且兩者均顯著高于無斑塊亞組(33.1％)(穩定斑塊亞組與無斑塊亞組比較:x2 =9.970,P=0.002;不穩定斑塊亞組與穩定斑塊亞組比較:x2=11.680,P=0.001;不穩定斑塊亞組與無斑塊亞組比較:x2 =39.532,P=0.000).多變量logistic迴歸分析顯示,高血壓(OR9.513,95％ CI1.291 ～20.779;P =0.028)、TC水平增高(OR 4.235,95％ Cl 1.069 ～ 19.034；P=0.032)、LDL水平增高(OR 4.201,95％ CI 1.803 ～9.672；P=0.001)以及攜帶C等位基因(OR 1.759,95％ CI 1.177～2.738;P =0.006)是大動脈粥樣硬化性卒中的獨立危險因素.結論 CD40 - 1C/T基因多態性與頸動脈粥樣硬化斑塊形成、不穩定性以及缺血性卒中風險相關,C等位基因可能為大動脈粥樣硬化性卒中的易感因素.
목적 탐토CD40기인계동자구- 1C/T기인다태성여경동맥죽양경화반괴화대동맥죽양경화성졸중적상관성.방법 연구대상위급성대동맥죽양경화성졸중환자(병례조)화무졸중사적체검자(대조조).병례조진일보분위불은정반괴아조、은정반괴아조화무반괴아조.채용취합매련반응-한제성편단장도다태성기술검측CD40 - 1C/T기인다태성.결과 공납입대동맥죽양경화성졸중환자170례(병례조)화61명무졸중사적체검자(대조조).재병례조중,불은정반괴아조51례,은정반괴아조60례,무반괴아조59례.병례조C등위기인빈솔현저고우대조조(52.9％대38.5％;x2=7.466,P=0.006).재병례조중,불은정반괴아조C등위기인빈솔(75.5％)현저성고우은정반괴아조(53.3％),차량자균현저고우무반괴아조(33.1％)(은정반괴아조여무반괴아조비교:x2 =9.970,P=0.002;불은정반괴아조여은정반괴아조비교:x2=11.680,P=0.001;불은정반괴아조여무반괴아조비교:x2 =39.532,P=0.000).다변량logistic회귀분석현시,고혈압(OR9.513,95％ CI1.291 ～20.779;P =0.028)、TC수평증고(OR 4.235,95％ Cl 1.069 ～ 19.034；P=0.032)、LDL수평증고(OR 4.201,95％ CI 1.803 ～9.672；P=0.001)이급휴대C등위기인(OR 1.759,95％ CI 1.177～2.738;P =0.006)시대동맥죽양경화성졸중적독립위험인소.결론 CD40 - 1C/T기인다태성여경동맥죽양경화반괴형성、불은정성이급결혈성졸중풍험상관,C등위기인가능위대동맥죽양경화성졸중적역감인소.
Objective To investigate the correlation between CD40 gene promoter region - 1C/T polymorphism and carotid atherosclerotic plaques and large artery atherosclerotic stroke.Methods The subjects were the patients with acute large artery atherosclerotic stroke (patient group) and the patients without history of stroke (control group).The patient group was further divided into an unstable plaque subgroup,a stable plaque subgroup,and a plaque-free subgroup.Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect CD40 - 1C/T polymorphism.Results A total of 170 patients with large artery atherosclerotic stroke (patient group) and 61 subjects without history of stroke (control group) were included.In the patient group,51 patients were in the unstable plaque subgroup,60 were in the stable plaque subgroup,and 59 were in the plaque-free subgroup.C allele frequency of the patient group was significantly higher than that of the comrol group (52.9％ vs.38.5％ ;x2 =7.466,P =0.006).In the patient group,C allele frequency of the unstable plaque subgroup (75.5％) was significantly higher than that of the stable plaque subgroup (53.3％),and both of them were significantly higher than that of the plaque-free subgroup (33.1％ ) (the stable plaque subgroup vs.the plaque-free subgroup:x2 =9.970,P =0.002; the unstable plaque subgroup vs.the stable plaque subgroups:x2 =11.680,P =0.001; the unstable plaque subgroup vs.the plaque-free subgroup:x2 =39.532,P=0.000).Multivariate logistic regressive analysis showed that hypertension (OR9.513,95％ CI 1.291 - 20.779; P =0.028),increased total cholesterol level (OR 4.235,95％ CI 1.069 -19.034; P =0.032),increased low density lipoprotein level( OR 4.201,95％ CI 1.803 - 9.672; P =0.001 )and C alleles (OR 1.759,95％ CI 1.177 - 2.738; P =0.006) are the independent risk factors of large artery atherosclerotic stroke.Conclusions CD40 - 1C/T polymorphism is associated with the risks of carotid atherosclerotic plaque formation,unstable plaque and large artery atherosclerotic stroke; C allele may be a susceptibility factor for large artery atherosclerotic stroke.
