CAJ | 학술논문

目的探讨声触诊组织量化(VTQ)技术对进展期胃癌Lauren分型的评估价值.方法对术前胃镜活检术后经病理证实的41例胃癌患者术前行VTQ检查,测量各病灶组织的剪切波速度(SWV),术后对胃癌标本行HE染色及AB-PAS黏液染色,并据此进行Lauren分型.比较胃癌不同Lauren亚型间SWV的差异.结果 41例胃癌标本组织学诊断为弥漫型者26例,肠型者15例.弥漫型胃癌SWV明显高于肠型胃癌,差异有统计学意义[(1.72±0.83) m/s对(1.05±0.66)m/s,t=2.819,P=0.008].由ROC曲线可知,当SWV截值=1.045m/s(曲线下最大面积=0.795)时,其预测弥漫型胃癌的敏感性和特异性分别为80.8％和73.3％.结论利用VTQ检查可以在术前初步判断进展期胃癌的Lauren分型.
목적 탐토성촉진조직양화(VTQ)기술대진전기위암Lauren분형적평고개치.방법 대술전위경활검술후경병리증실적41례위암환자술전행VTQ검사,측량각병조조직적전절파속도(SWV),술후대위암표본행HE염색급AB-PAS점액염색,병거차진행Lauren분형.비교위암불동Lauren아형간SWV적차이.결과 41례위암표본조직학진단위미만형자26례,장형자15례.미만형위암SWV명현고우장형위암,차이유통계학의의[(1.72±0.83) m/s대(1.05±0.66)m/s,t=2.819,P=0.008].유ROC곡선가지,당SWV절치=1.045m/s(곡선하최대면적=0.795)시,기예측미만형위암적민감성화특이성분별위80.8％화73.3％.결론 이용VTQ검사가이재술전초보판단진전기위암적Lauren분형.
Objective To explore the value of virtual touch tissue quantification (VTQ) in evaluating Lauren classification of advanced gastric carcinoma.Methods Forty-one patients with gastric cancer proved by endoscopic biopsy performed preoperative VTQ examination,and the findings were compared with postoperative pathologic results via hematoxylin -eosin and Alcian Blue-Periodic Acid Schiff (AB-PAS) staining.Results In 41 patients,26 cases were diagnosed as diffuse type and 15 cases as intestinal type by pathology after operation.The shear wave velocity(SWV) of diffuse type was higher than that of intestinal type [(1.72± 0.83)m/s vs (1.05± 0.66)m/s,t =2.819,P=0.008] measured by virtual touch tissue quantification (VTQ).According to the area under the ROC curve,the cut- off value of SWV in gastric cancer tissues for assessing the diffuse type was 1.045 m/s with a sensitivity of 80.8％ and specificity of 73.3 ％ respectively.Conclusions VTQ could be considered as a promising method to distinguish the Lauren classification in patients with advanced gastric carcinoma.