中华外科杂志
中華外科雜誌
중화외과잡지
CHINESE JOURNAL OF SURGERY
2012年
6期
551-554
,共4页
禚洪庆%张彦斌%张辉%郭鹏%吕游%董令仪%姜可伟%叶颖江%王杉
禚洪慶%張彥斌%張輝%郭鵬%呂遊%董令儀%薑可偉%葉穎江%王杉
작홍경%장언빈%장휘%곽붕%려유%동령의%강가위%협영강%왕삼
结直肠肿瘤%微丝蛋白质类%肌蛋白质类%免疫组织化学%组织阵列分析%预后
結直腸腫瘤%微絲蛋白質類%肌蛋白質類%免疫組織化學%組織陣列分析%預後
결직장종류%미사단백질류%기단백질류%면역조직화학%조직진렬분석%예후
Colorectal neoplasms% Microfilament proteins% Muscle proteins%Immunohistochemistry%Tissue array analysis%Pronosis
目的 探讨结直肠癌组织中肌动蛋白结合蛋白transgelin-2的表达及其与临床病理因素的关系,评价transgelin-2在结直肠癌预后判断中的价值.方法 应用组织芯片结合免疫组化方法,检测2002年9月至2004年4月120例手术切除的结直肠癌患者组织中transgelin-2的表达情况,男性74例,女性46例,年龄26～89岁,中位年龄64.5岁.采用x2检验其与临床病理因素的关系,Log-rank检测生存率差别,Cox比例风险模型分析多个变量对生存时间的影响.结果 transgelin-2在结直肠癌组织中的阳性表达率为69.2％.transgelin-2的表达与分化程度(x2=5.420)、淋巴结转移(x2＝45.577)、远处转移(x2=12.009)及TNM分期(x2=47.577)相关(P＜0.05).transelin-2阳性表达者术后生存时间(39±5)个月,阴性表达者为( 59±3)个月,Kaplan-Meier生存分析显示,transgelin-2表达与生存时间密切相关(P =0.003).Cox分析显示,远处转移(RR=8.318,95％ CI:4.119～16.790)、淋巴结转移(RR=2.794,95％ CI:1.246～6.263)和transgelin-2表达(RR=1.834,95％ CI:1.118～2.793)是影响结直肠癌患者预后的独立因素(P＜0.05).结论 肌动蛋白结合蛋白transgelin-2的表达水平与结直肠癌临床病理因素及预后相关,可能成为判断结直肠癌转移和预后的潜在标志物.
目的 探討結直腸癌組織中肌動蛋白結閤蛋白transgelin-2的錶達及其與臨床病理因素的關繫,評價transgelin-2在結直腸癌預後判斷中的價值.方法 應用組織芯片結閤免疫組化方法,檢測2002年9月至2004年4月120例手術切除的結直腸癌患者組織中transgelin-2的錶達情況,男性74例,女性46例,年齡26～89歲,中位年齡64.5歲.採用x2檢驗其與臨床病理因素的關繫,Log-rank檢測生存率差彆,Cox比例風險模型分析多箇變量對生存時間的影響.結果 transgelin-2在結直腸癌組織中的暘性錶達率為69.2％.transgelin-2的錶達與分化程度(x2=5.420)、淋巴結轉移(x2＝45.577)、遠處轉移(x2=12.009)及TNM分期(x2=47.577)相關(P＜0.05).transelin-2暘性錶達者術後生存時間(39±5)箇月,陰性錶達者為( 59±3)箇月,Kaplan-Meier生存分析顯示,transgelin-2錶達與生存時間密切相關(P =0.003).Cox分析顯示,遠處轉移(RR=8.318,95％ CI:4.119～16.790)、淋巴結轉移(RR=2.794,95％ CI:1.246～6.263)和transgelin-2錶達(RR=1.834,95％ CI:1.118～2.793)是影響結直腸癌患者預後的獨立因素(P＜0.05).結論 肌動蛋白結閤蛋白transgelin-2的錶達水平與結直腸癌臨床病理因素及預後相關,可能成為判斷結直腸癌轉移和預後的潛在標誌物.
목적 탐토결직장암조직중기동단백결합단백transgelin-2적표체급기여림상병리인소적관계,평개transgelin-2재결직장암예후판단중적개치.방법 응용조직심편결합면역조화방법,검측2002년9월지2004년4월120례수술절제적결직장암환자조직중transgelin-2적표체정황,남성74례,녀성46례,년령26～89세,중위년령64.5세.채용x2검험기여림상병리인소적관계,Log-rank검측생존솔차별,Cox비례풍험모형분석다개변량대생존시간적영향.결과 transgelin-2재결직장암조직중적양성표체솔위69.2％.transgelin-2적표체여분화정도(x2=5.420)、림파결전이(x2＝45.577)、원처전이(x2=12.009)급TNM분기(x2=47.577)상관(P＜0.05).transelin-2양성표체자술후생존시간(39±5)개월,음성표체자위( 59±3)개월,Kaplan-Meier생존분석현시,transgelin-2표체여생존시간밀절상관(P =0.003).Cox분석현시,원처전이(RR=8.318,95％ CI:4.119～16.790)、림파결전이(RR=2.794,95％ CI:1.246～6.263)화transgelin-2표체(RR=1.834,95％ CI:1.118～2.793)시영향결직장암환자예후적독립인소(P＜0.05).결론 기동단백결합단백transgelin-2적표체수평여결직장암림상병리인소급예후상관,가능성위판단결직장암전이화예후적잠재표지물.
Objectives To investigate the relationship between the expression of transgelin-2 and the clinicopathological factors of colorectal carcinoma and evaluate the value of transgelin-2 in prognostic assessment of the colorectal cancer patients.Methods Using tissue microarray and immunohistochemical methods,we examined transgelin-2 of 120 colorectal cancer patients received surgical treatment from September 2002 to April 2004,including 74 male and 46 female,age from 26 to 89 years.Analyzed the relationship between transgelin-2 and both the clinicpathologcial features and prognosis of the colorectal cancer by using x2 test and Kaplan-Meier survival analysis.Cox proportion hazard regression analysis was used to study the independent prognostic factors.Results The positive rate of transgelin-2 expression was 69.2％ in colorectal carcinoma. The transgelin-2 expression correlated with differentiation degree ( x2 =5.420),Iymph nodes metastasis ( x2 =45.577 ),distant metastasis ( x2 =12.009 ),and TNM staging (x2 =47.577).The survival time was (39 ±5 ) months in patients with positive expression of the trangelin-2,while (59 ± 3 ) months in patients with negative expression.The patient's survival time was statistically correlated with the transgelin-2 expression (P =0.003 ).Distant metastasis (RR =8.318,95％CI:4.119-16.790),lymph nodes metastasis (RR =2.794,95％ CI:1.246-6.263) and transgelin-2 expression (RR =1.834,95％ CI:1.118-2.973) were independent prognostic factors in patients with colorectal cancer (P ＜ 0.05 ). Conclusions The expression of transgelin-2 is conelated withclinicopathological features and prognosis in colorectal cancer,may be the potential marker of metastasis and the prognosis of colorectal cancer patients.
