中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2010年
13期
10-12
,共3页
寇根生%张宁%张建宏%陈佐明
寇根生%張寧%張建宏%陳佐明
구근생%장저%장건굉%진좌명
精神分裂症%抑郁症%探究性眼动分析%事件相关电位
精神分裂癥%抑鬱癥%探究性眼動分析%事件相關電位
정신분렬증%억욱증%탐구성안동분석%사건상관전위
Schizophrenia%Depression%Exploratory eye movement%Event-related potentials
目的 探讨精神分裂症及抑郁症患者的探究性眼动(EEM)和事件相关电位(ERP)的不同特征.方法 对50例精神分裂症及48例抑郁症患者治疗前后分别进行了EEM和ERP测定,并将结果与正常对照组加以比较.结果 精神分裂症组患者EEM和ERP测定的异常率分别为96%(48/50)和92%(46/50),而抑郁症组患者EEM和ERP测定的异常率为87.5%(42/48)和83.3%(40/48),两组EEM和ERP测定的异常率比较差异无统计学意义(χ2=1.172和2.360,P=0.191和0.124);精神分裂症和抑郁症组EEM测定凝视点(NEF)及反应探索评分(RSS)值较对照组减少,D值增加,其差异有统计学意义(P<0.01),而两病例组相比,EEM各指标测定结果差异有统计学意义(P<0.01);精神分裂症和抑郁症组ERP测定N2及P3波潜伏期较对照组延长,P3波幅降低,其差异有统计学意义(P<0.01),而两病例组相比,ERP测定N2及P3波测定结果差异有统计学意义(P<0.01).结论 EEM和ERP测定可作为精神分裂症和抑郁症患者诊断指标应用于临床.
目的 探討精神分裂癥及抑鬱癥患者的探究性眼動(EEM)和事件相關電位(ERP)的不同特徵.方法 對50例精神分裂癥及48例抑鬱癥患者治療前後分彆進行瞭EEM和ERP測定,併將結果與正常對照組加以比較.結果 精神分裂癥組患者EEM和ERP測定的異常率分彆為96%(48/50)和92%(46/50),而抑鬱癥組患者EEM和ERP測定的異常率為87.5%(42/48)和83.3%(40/48),兩組EEM和ERP測定的異常率比較差異無統計學意義(χ2=1.172和2.360,P=0.191和0.124);精神分裂癥和抑鬱癥組EEM測定凝視點(NEF)及反應探索評分(RSS)值較對照組減少,D值增加,其差異有統計學意義(P<0.01),而兩病例組相比,EEM各指標測定結果差異有統計學意義(P<0.01);精神分裂癥和抑鬱癥組ERP測定N2及P3波潛伏期較對照組延長,P3波幅降低,其差異有統計學意義(P<0.01),而兩病例組相比,ERP測定N2及P3波測定結果差異有統計學意義(P<0.01).結論 EEM和ERP測定可作為精神分裂癥和抑鬱癥患者診斷指標應用于臨床.
목적 탐토정신분렬증급억욱증환자적탐구성안동(EEM)화사건상관전위(ERP)적불동특정.방법 대50례정신분렬증급48례억욱증환자치료전후분별진행료EEM화ERP측정,병장결과여정상대조조가이비교.결과 정신분렬증조환자EEM화ERP측정적이상솔분별위96%(48/50)화92%(46/50),이억욱증조환자EEM화ERP측정적이상솔위87.5%(42/48)화83.3%(40/48),량조EEM화ERP측정적이상솔비교차이무통계학의의(χ2=1.172화2.360,P=0.191화0.124);정신분렬증화억욱증조EEM측정응시점(NEF)급반응탐색평분(RSS)치교대조조감소,D치증가,기차이유통계학의의(P<0.01),이량병례조상비,EEM각지표측정결과차이유통계학의의(P<0.01);정신분렬증화억욱증조ERP측정N2급P3파잠복기교대조조연장,P3파폭강저,기차이유통계학의의(P<0.01),이량병례조상비,ERP측정N2급P3파측정결과차이유통계학의의(P<0.01).결론 EEM화ERP측정가작위정신분렬증화억욱증환자진단지표응용우림상.
Objective To explore the different feature on exploratory eye movement(EEM) and event-related potentials(ERP) with schizophrenia and depression Patients.Methods EEM and ERP test were used for fifty schizophrenia and forty-eight depression patients,and the results were compared with the normal healthy peoples.Results The abnormal rate of EEM and ERP test with schizophrenia group were 96%(48/50) and 92%(46/50), and the abnormal rate of EEM and ERP test with depression group were 87.5%(42/48) and 83.3% (40/48). The abnormal rate of EEM and ERP with the two groups have no significant difference (χ2=1.172, 2.360, P=0.191, 0.124). The number of eye fixation (NEF) and the responsive search score (RSS) of schizophrenia and depression group were significant lower and the scores of discriminant (D) were significant higher than those with the normal control group (P<0.01), and the indexes of EEM have a significant difference between the two groups (P<0.01). The latency of N2 and P3 of ERP and the amplitude of P3 were significant longer and lowwer than those with the normal control group (P<0.01), and the indexes of N2 and P3 of ERP had significant differences between the two groups (P<0.01).Conclusions EEM and ERP test can be used the diadynamic criteriaes for clinic with schizophrenia and depression patients.
