CAJ | 학술논문

目的观察并比较旋转磁场与止吐药盐酸格拉司琼防治顺铂化疗所致恶心呕吐的疗效及不良反应.方法将68例接受顺铂方案化疗的患者随机为磁场治疗组组和药物治疗组,每组34例,采用对照研究方法,分别采用旋转磁场和静脉注射止吐药盐酸格拉司琼治疗,观察2种方法的止吐效果和不良反应.结果在急性期,旋转磁场和盐酸格拉司琼均能有效防治顺铂所致呕吐反应,有效率分别为88.2%和91.2%,差异无统计学意义(P>0.05);而在延迟期,磁场治疗有效率为92.6%,药物治疗为80.9%,差异有统计学意义(P<0.05);治疗相关不良反应,磁场治疗组为20.6%,药物治疗组为45.6%,差异有统计学意义(P<0.01).结论旋转磁场与止吐药盐酸格拉司琼对化疗所引起的急性呕吐的疗效相当,对迟发性呕吐的防治作用显著优于止吐药盐酸格拉司琼,且不良反应更轻.
목적 관찰병비교선전자장여지토약염산격랍사경방치순박화료소치악심구토적료효급불량반응.방법 장68례접수순박방안화료적환자수궤위자장치료조조화약물치료조,매조34례,채용대조연구방법,분별채용선전자장화정맥주사지토약염산격랍사경치료,관찰2충방법적지토효과화불량반응.결과 재급성기,선전자장화염산격랍사경균능유효방치순박소치구토반응,유효솔분별위88.2%화91.2%,차이무통계학의의(P>0.05);이재연지기,자장치료유효솔위92.6%,약물치료위80.9%,차이유통계학의의(P<0.05);치료상관불량반응,자장치료조위20.6%,약물치료조위45.6%,차이유통계학의의(P<0.01).결론 선전자장여지토약염산격랍사경대화료소인기적급성구토적료효상당,대지발성구토적방치작용현저우우지토약염산격랍사경,차불량반응경경.
Objective To observe the efficacy of a rotating magnetic field and granisetron hydrochloride in preventing nausea and vomiting caused by a eisplatin regimen, and any side effects. Methods Sixty-eight patients receiving cisplatin regimen chemotherapy were randomly assigned to two groups: a magnetic treatment group and a drug treatment group. The patients in the two groups were exposed to a rotating magnetic field or received granisetron hydrochloride, respectively. The effects of the treatments were observed. Results Both treatments could effectively prevent and treat the vomiting caused by chemotherapy. The rate of response to the rotating magnetic field was 88.2% and to the drug 91.2%. However, tardive vomiting was significantly better controlled in the rotating magnetic field group. The incidence of side effects in the magnetic field group was 20.6% , and in the drug treatment group it was 45.6%. Conclusion The efficacy of a rotating magnetic field and granisetron in treating acute vomiting were simi- lar. The rotating magnetic field was more effective in preventing tardive vomiting and had fewer side effects. Magnetic therapy should be more generally applied in clinical practice.