中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2012年
1期
27-30
,共4页
蛛网膜下腔出血%神经功能评分%量化分析
蛛網膜下腔齣血%神經功能評分%量化分析
주망막하강출혈%신경공능평분%양화분석
Subarachnoid hemorrhage%Neurological scale%Quantitative analysis
目的 观察应用于小鼠血管内穿刺模型中的Sugawara出血量评分与Garcia神经功能评分间的相关关系. 方法 颈动脉穿刺法制作小鼠蛛网膜下腔出血(SAH)模型,造模后24 h应用Garcia神经功能评分评价小鼠神经功能缺损情况；然后处死小鼠,应用Sugawara出血量评分法对小鼠SAH出血情况进行评分.应用Spearman相关分析判断出血量评分与神经功能评分间的相关关系. 结果 21只小鼠造模后存活14只,两项评分结果提示,出血量越多,神经功能越差,二者呈负相关(r=-0.841,P=0.000). 结论 神经功能评分法可初步替代影像学检查用来评价小鼠颈动脉穿刺模型中的出血量.
目的 觀察應用于小鼠血管內穿刺模型中的Sugawara齣血量評分與Garcia神經功能評分間的相關關繫. 方法 頸動脈穿刺法製作小鼠蛛網膜下腔齣血(SAH)模型,造模後24 h應用Garcia神經功能評分評價小鼠神經功能缺損情況；然後處死小鼠,應用Sugawara齣血量評分法對小鼠SAH齣血情況進行評分.應用Spearman相關分析判斷齣血量評分與神經功能評分間的相關關繫. 結果 21隻小鼠造模後存活14隻,兩項評分結果提示,齣血量越多,神經功能越差,二者呈負相關(r=-0.841,P=0.000). 結論 神經功能評分法可初步替代影像學檢查用來評價小鼠頸動脈穿刺模型中的齣血量.
목적 관찰응용우소서혈관내천자모형중적Sugawara출혈량평분여Garcia신경공능평분간적상관관계. 방법 경동맥천자법제작소서주망막하강출혈(SAH)모형,조모후24 h응용Garcia신경공능평분평개소서신경공능결손정황；연후처사소서,응용Sugawara출혈량평분법대소서SAH출혈정황진행평분.응용Spearman상관분석판단출혈량평분여신경공능평분간적상관관계. 결과 21지소서조모후존활14지,량항평분결과제시,출혈량월다,신경공능월차,이자정부상관(r=-0.841,P=0.000). 결론 신경공능평분법가초보체대영상학검사용래평개소서경동맥천자모형중적출혈량.
Objective To observe the quantitative relation between new subarachnoid hemorrhage (SAH) grading and scores of Garcia neurological scale in mouse models of SAH.Methods Mouse models of SAH were induced by filament perforation; neurological scale was performed 24 h after SAH; and then,these mouse models were sacrificed and performed SAH grading;the relation between scores of neurological scale and SAH grading was analyzed by SPSS 13.0 software.Results Fourteen of 21 mice survived after SAH. The higher the SAH grading, the worsen the neurological scale results; these 2 were negatively correlated (r=-0.841,P=0.000). Conclusion The scores of Garcia neurological scale and SAH grading has a quantitative negative relation and can be used to evaluate the hemorrhage in mouse models induced by filament perforation.
