中国医药
中國醫藥
중국의약
CHINA MEDICINE
2010年
3期
223-224
,共2页
肺结核%老年%药物不良反应
肺結覈%老年%藥物不良反應
폐결핵%노년%약물불량반응
Pulmonary tuberculosis%Elderly patients%Adverse drug reaction
目的 提高老年肺结核患者的治疗效果,保证疗程的顺利完成.方法 对186例60岁以上老人肺结核患者(老年组)及198例20～60岁青壮年肺结核患者(青壮年组)在抗结核药物治疗过程中出现的不良反应进行对比分析,探讨防治不良反应的有效方法.结果 老年组患者抗结核药物不良反应发生率为62%(115例),青壮年组患者抗结核药物不良反应发生率为32%(58例).老年组患者在接受治疗15 d内出现不良反应53例,15～30 d 28例,30～60 d约20例,2个月以上14例.青壮年组患者在接受治疗15 d内出现不良反应32例,15～30 d 18例,30～60 d约10例,2个月以上8例.结论 老年肺结核患者在使用抗结核药物时出现不良反应较明显,且出现时间早,故制订合理的抗结核化疗方案,掌握好用药剂量,使用合理的护肝用其他预防副作用的药物,可以减少不良反应的发生,保障抗结核治疗的顺利完成.
目的 提高老年肺結覈患者的治療效果,保證療程的順利完成.方法 對186例60歲以上老人肺結覈患者(老年組)及198例20～60歲青壯年肺結覈患者(青壯年組)在抗結覈藥物治療過程中齣現的不良反應進行對比分析,探討防治不良反應的有效方法.結果 老年組患者抗結覈藥物不良反應髮生率為62%(115例),青壯年組患者抗結覈藥物不良反應髮生率為32%(58例).老年組患者在接受治療15 d內齣現不良反應53例,15～30 d 28例,30～60 d約20例,2箇月以上14例.青壯年組患者在接受治療15 d內齣現不良反應32例,15～30 d 18例,30～60 d約10例,2箇月以上8例.結論 老年肺結覈患者在使用抗結覈藥物時齣現不良反應較明顯,且齣現時間早,故製訂閤理的抗結覈化療方案,掌握好用藥劑量,使用閤理的護肝用其他預防副作用的藥物,可以減少不良反應的髮生,保障抗結覈治療的順利完成.
목적 제고노년폐결핵환자적치료효과,보증료정적순리완성.방법 대186례60세이상노인폐결핵환자(노년조)급198례20～60세청장년폐결핵환자(청장년조)재항결핵약물치료과정중출현적불량반응진행대비분석,탐토방치불량반응적유효방법.결과 노년조환자항결핵약물불량반응발생솔위62%(115례),청장년조환자항결핵약물불량반응발생솔위32%(58례).노년조환자재접수치료15 d내출현불량반응53례,15～30 d 28례,30～60 d약20례,2개월이상14례.청장년조환자재접수치료15 d내출현불량반응32례,15～30 d 18례,30～60 d약10례,2개월이상8례.결론 노년폐결핵환자재사용항결핵약물시출현불량반응교명현,차출현시간조,고제정합리적항결핵화료방안,장악호용약제량,사용합리적호간용기타예방부작용적약물,가이감소불량반응적발생,보장항결핵치료적순리완성.
Objective To observe therapeutic effect of tuberculosis in elderly patients. Methods One hundred and eighty-six elderly patients(> 60 years old) and one hundred and nighty-eight patients (20-60 years old) were observed. Adverse drug reactions and methods of preventing adverse drug reactions during the treatment with anti-tuberculosis drug were analyzed. Results Adverse reaction rate in elderly patients was 62% (115 cases) and 32% (58 cases) in 20-60 years' old patients. Among elderly patients, 53 cases had adverse reactions in 15 days after treatment started, 28 cases between 15 and 30 days, 14 cases between 1 to 2 months, and 14 cases in o-ver 2 months. Thirty-two cases among 20-60 years' old patients got adverse reactions in 15 days, and 18 cases be-tween 15 to 30 days, 10 cases between 1 to 2 months, and 8 cases over 2 months. Conclusions Adverse reaction occurs earlier and more frequently in elderly patients than that in young and middle-aged patients. An reasonable chemotherapeutic plan and proper dosage of chemotherapy drugs can reduce adverse reactions and accomplish the courses of anti-tuberculosis treatment.
