中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2010年
17期
2314-2315
,共2页
徐风亮%吴鹏%任清霞%田玉峰
徐風亮%吳鵬%任清霞%田玉峰
서풍량%오붕%임청하%전옥봉
乳腺肿瘤%体液和分泌液%肿瘤相关抗原153%癌胚抗原
乳腺腫瘤%體液和分泌液%腫瘤相關抗原153%癌胚抗原
유선종류%체액화분비액%종류상관항원153%암배항원
Breast neoplasms%Fluids and secretions%CA153 antigen%Carcinoembryonic antigen
目的 探讨乳头溢液肿瘤标志物癌抗原相关蛋白153(CA153)和癌胚抗原(CEA)检测在乳腺癌早期诊断中的价值.方法 对153例乳头溢液患者按疾病类型分为良性病变组91例(均为乳腺良性病变患者)和乳腺癌组62例(均为乳腺癌患者),同时选取同期正常分娩的产妇40例为对照组,应用电化学发光法检测各组乳头溢液和血清CA153、CEA水平.结果 乳腺癌组乳头溢液CA153、CEA明显高于良性病变组和对照组(CA153:t=28.949、33.844;CEA:t=19.773、16.623,均P<0.01),乳头溢液肿瘤标志物阳性检出率明显高于血清阳性检出率(均P<0.05).结论 乳腺癌患者乳头溢液肿瘤标志物CA153、CEA阳性检出率高于血清阳性检出率,对早期诊断乳腺癌具有重要价值.
目的 探討乳頭溢液腫瘤標誌物癌抗原相關蛋白153(CA153)和癌胚抗原(CEA)檢測在乳腺癌早期診斷中的價值.方法 對153例乳頭溢液患者按疾病類型分為良性病變組91例(均為乳腺良性病變患者)和乳腺癌組62例(均為乳腺癌患者),同時選取同期正常分娩的產婦40例為對照組,應用電化學髮光法檢測各組乳頭溢液和血清CA153、CEA水平.結果 乳腺癌組乳頭溢液CA153、CEA明顯高于良性病變組和對照組(CA153:t=28.949、33.844;CEA:t=19.773、16.623,均P<0.01),乳頭溢液腫瘤標誌物暘性檢齣率明顯高于血清暘性檢齣率(均P<0.05).結論 乳腺癌患者乳頭溢液腫瘤標誌物CA153、CEA暘性檢齣率高于血清暘性檢齣率,對早期診斷乳腺癌具有重要價值.
목적 탐토유두일액종류표지물암항원상관단백153(CA153)화암배항원(CEA)검측재유선암조기진단중적개치.방법 대153례유두일액환자안질병류형분위량성병변조91례(균위유선량성병변환자)화유선암조62례(균위유선암환자),동시선취동기정상분면적산부40례위대조조,응용전화학발광법검측각조유두일액화혈청CA153、CEA수평.결과 유선암조유두일액CA153、CEA명현고우량성병변조화대조조(CA153:t=28.949、33.844;CEA:t=19.773、16.623,균P<0.01),유두일액종류표지물양성검출솔명현고우혈청양성검출솔(균P<0.05).결론 유선암환자유두일액종류표지물CA153、CEA양성검출솔고우혈청양성검출솔,대조기진단유선암구유중요개치.
Objective To study the clinical value of nipple discharge detection in the early diagnosis of breast cancer,CA153 ,CEA levels were measured both in nipple discharge and serum. Methods 153 consecutive patients with nipple discharge in Rizhao hospital were studied,among them there were 91 cases with breast cancer and 62 cases with benign disease. The nipple discharged and serum from the 153 cases with nipple discharged were collected and CA153, CEA levels were measured with electrochemiluminescence method. Results The CA153, CEA levels of nipple discharge in breast cancer were significantly higher than the control group(CA153:t =28.949,33.844;CEA:t = 19.773,16.623, all P < 0.01). The positive rate of CA153, CEA in nipple discharge were significantly higher than in the serum (P < 0.05). Conclusion The positive rate of CA153, CEA in nipple discharge were significantly higher than in the serum. The detection of CA153 ,CEA had important value in the early diagnosis of breast cancer.