CAJ | 학술논문

背景体外循环(cardiopulmonary bypass,CPB)转机过程对患者红细胞的损伤是临床常见的病理过程.大量动物文献报道表明,丙酮酸盐能通过多个途径保护和恢复器官/细胞的功能,现就丙酬酸盐对红细胞的影响机制及在CPB中的应用前景作一综述; 目的阐述丙酮酸盐对红细胞的影响机制,展望丙酮酸盐在CPB中的应用前景;内容作为糖酵解中间产物的丙酮酸盐可通过促进细胞能量代谢,抗氧化和纠正细胞内酸中毒3种途径修复细胞损伤,恢复其功能,丙酮酸盐的这些作用机制可能适用于CPB过程中红细胞的保护;趋向丙酮酸盐在CPB中应用可能为临床红细胞的保护提供新途径.
배경 체외순배(cardiopulmonary bypass,CPB)전궤과정대환자홍세포적손상시림상상견적병리과정.대량동물문헌보도표명,병동산염능통과다개도경보호화회복기관/세포적공능,현취병수산염대홍세포적영향궤제급재CPB중적응용전경작일종술; 목적 천술병동산염대홍세포적영향궤제,전망병동산염재CPB중적응용전경;내용 작위당효해중간산물적병동산염가통과촉진세포능량대사,항양화화규정세포내산중독3충도경수복세포손상,회복기공능,병동산염적저사작용궤제가능괄용우CPB과정중홍세포적보호;추향 병동산염재CPB중응용가능위림상홍세포적보호제공신도경.
Background Various damage to red blood cells occurs during cardiopulmonary bypass (CPB). Multiple animal studies in literature indicated that pyruvate can protect and restore organ/cell function through multiple ways. This article reviewed the protective effect of pyruvate and its mechanisms on RBC during CPB. Objective Discussion of the effect and mechanisms of pyruvate on RBC. Content As an intermediate product of glycolysis, pyruvate can repair the RBC damage through anti-oxidation, modulation of energy metabolism and correction of metabolic acidosis, preserving RBC function, which might be applied to protect RBC during CPB. Trent Pyruvate in CPB of application might provide a new way of RBC protection.