国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
19期
1471-1473
,共3页
次大面积肺栓塞%溶栓治疗%重组组织型纤溶酶原激活剂
次大麵積肺栓塞%溶栓治療%重組組織型纖溶酶原激活劑
차대면적폐전새%용전치료%중조조직형섬용매원격활제
Submassive pulmonary embolism%Thrombolysis%Recombinant tissue plasminogen activator
目的 观察溶栓及抗凝治疗次大面积肺栓塞患者的疗效.方法 56例次大面积肺栓塞患者入院时随机分为溶栓组及抗凝组,溶栓组给予重组组织型纤溶酶原激活剂(rt-PA)溶栓后序贯抗凝治疗(低分子肝素及华法林),抗凝组单纯给予抗凝治疗,并观察总有效率及出血发生率.结果 溶栓组总有效率为96.4％,高于抗凝组(65.4％,P＜0.05).两组均无颅内出血及其他部位严重出血病例,出血发生率无显著性差别(P＞0.05).结论 对次大面积肺栓塞患者,在无溶栓禁忌证的情况下,首选rt-PA溶栓治疗,可迅速改善肺栓塞所致右室功能不全症状,提高治疗有效率.
目的 觀察溶栓及抗凝治療次大麵積肺栓塞患者的療效.方法 56例次大麵積肺栓塞患者入院時隨機分為溶栓組及抗凝組,溶栓組給予重組組織型纖溶酶原激活劑(rt-PA)溶栓後序貫抗凝治療(低分子肝素及華法林),抗凝組單純給予抗凝治療,併觀察總有效率及齣血髮生率.結果 溶栓組總有效率為96.4％,高于抗凝組(65.4％,P＜0.05).兩組均無顱內齣血及其他部位嚴重齣血病例,齣血髮生率無顯著性差彆(P＞0.05).結論 對次大麵積肺栓塞患者,在無溶栓禁忌證的情況下,首選rt-PA溶栓治療,可迅速改善肺栓塞所緻右室功能不全癥狀,提高治療有效率.
목적 관찰용전급항응치료차대면적폐전새환자적료효.방법 56례차대면적폐전새환자입원시수궤분위용전조급항응조,용전조급여중조조직형섬용매원격활제(rt-PA)용전후서관항응치료(저분자간소급화법림),항응조단순급여항응치료,병관찰총유효솔급출혈발생솔.결과 용전조총유효솔위96.4％,고우항응조(65.4％,P＜0.05).량조균무로내출혈급기타부위엄중출혈병례,출혈발생솔무현저성차별(P＞0.05).결론 대차대면적폐전새환자,재무용전금기증적정황하,수선rt-PA용전치료,가신속개선폐전새소치우실공능불전증상,제고치료유효솔.
Objective To observe the curative effect of thrombolysis and anticoagulant therapy on submassive pulmonary emblism (PE) patients.Methods Fifty six submassive PE patients were randomly divided thrombolysis group and anticoagulant group.The thrombolysis group were given thrombolysis therapy with Recombinant tissue plasminogen activator (rt-PA) and given anticoagulant therapy (Low molecular heparin and Warfarin) sequentially.The anticoagulant group were given anticoagulant therapy merely.The total effective rate and bleeding rate were observed.Results The total effective rate were 96.4％ in thrombolysis group and higher than that in anticoagulant group (65.4％,P ＜ 0.05).There were no intracranial hemorrhages and severe hemorrhages of other body parts.There was no significant difference in bleeding incidence rate between the two groups (P ＞ 0.05).Conclusions If there is no contraindication of thrombolysis we should choice thrombolysis to treat submassive PE patients that can improve the symptoms of right ventricle dysfunction quickly and increase the effective treatment rate.
