CAJ | 학술논문

经活检证实的慢性活动性肝炎(CAH)26例,等分成两组,甲组静脉输注胎肝细胞(FLC)悬液治疗共25次,每例1～4次,每次输入有核细胞数为1.1～5.4×l09个;乙组用转移因子(TF)4mg肌注或局部淋巴结旁注射,每周2次,疗程为3～18周.结果表明,两组ALT复常时间分别平均为62.3天及113.4天(P<0.05);抗-HBs转阳率为7/13及2/13例P<0.05);3个月的近期治愈率为86.4%与38.5%(P<0.025),平均住院日为74.2及115天(P<0.05).初步表明FLC输注疗效明显优于转移因子.
경활검증실적만성활동성간염(CAH)26례,등분성량조,갑조정맥수주태간세포(FLC)현액치료공25차,매례1～4차,매차수입유핵세포수위1.1～5.4×l09개;을조용전이인자(TF)4mg기주혹국부림파결방주사,매주2차,료정위3～18주.결과표명,량조ALT복상시간분별평균위62.3천급113.4천(P<0.05);항-HBs전양솔위7/13급2/13례P<0.05);3개월적근기치유솔위86.4%여38.5%(P<0.025),평균주원일위74.2급115천(P<0.05).초보표명FLC수주료효명현우우전이인자.
Thirteen patients with chronic active hepatitis(CAH)B were treated with perfusion of homologous fetal hepatic cells(FLC)for 25 times.In additional 13 patients with CAH B were treated wish transfer factor(TF)as controls.All cases of both groups were diagnosed by transoutaneous liver biopsy.The results showed that satisfactory effect was achieved in those cases treated with FLC suspension.In comparison with the controls,FLC treatmont showed the advantages as:(1)short-term(3 months)curative rate was higher(respectively 11/13 and 5/18,p<0.025);(2)serum ALT returned to normal more quickly(respectively 62.3±14.2 and 113.4±51.1 days p<0.001);(3)the positive rate,of anti-HBs was higher (respectively 7/18 and 2/18,p<0.05)and(4)the mean hospitalization was evidently shorter(respectively 74.2±16.4 and 115.0±19.2 days,p<0.001).The authors hold that the perfusion of FLO is effective and safe.It might deserve further trial.