CAJ | 학술논문

众多研究表明,氯胺酮不仅是临床上常用的镇痛药物和小儿麻醉药物,还具有非麻醉和镇痛方面的多种作用.后者包括对机体似乎相互矛盾的两方面的影响,一方面是抑制机体过度炎症反应、减轻兴奋性氨基酸对中枢神经系统兴奋毒性、维持细胞膜的稳定性以防有害物质外漏、消除反应氧化物、减轻氧自由基对细胞损伤等保护作用,另一方面可能影响神经系统发育、生长、以及形态结构和功能的维持.
음다연구표명,록알동불부시림상상상용적진통약물화소인마취약물,환구유비마취화진통방면적다충작용.후자포괄대궤체사호상호모순적량방면적영향,일방면시억제궤체과도염증반응、감경흥강성안기산대중추신경계통흥강독성、유지세포막적은정성이방유해물질외루、소제반응양화물、감경양자유기대세포손상등보호작용,령일방면가능영향신경계통발육、생장、이급형태결구화공능적유지.
A vast amount of researches conducted in animals and human have demonstrated that ketamine is not only a common medication used for pediatric anesthesia and analgesia,but also has non-anesthetic effects in two seemingly opposite aspects. On one hand.it exhibits neuroprotective effect by attenuating systemic inflammatory response, reducing the nuerotoxicity of exciting amino acids and stabilizing the metabolism of reactive oxygen species. On the other hand,ketamine may affect growth,development and function of nervous system.