CAJ | 학술논문

目的研究不同复苏液对热伤休克的家兔心肌功能的影响.方法40只家兔完全随机分为4组(每组10只):Ⅰ组:对照组(未热伤组)；Ⅱ组:0.9％生理盐水组；Ⅲ组:乳酸钠林格注射液组；Ⅳ组:醋酸钠林格注射液组.热伤达体表面积25％～30％后,液体输注速度以每1％热伤面积0.33 ml·kg-1·h-1持续4h.通过制备离体工作心脏模型测定各组心肌功能.结果 Ⅱ组的心输出量(cardiac output,CO)[分别是(85±9)、(90±9)、(102±11)、(103±10)、(99±10)、(101±11) ml/min]、等容收缩期左心室内压力上升的速率(dp/dt)[分别是(1 200±110)、(1 350±125)、(1 210±100)、(1 200±115)、(1 150±120)、(1 000±95)mmHg/s](1 mm Hg=0.133 kPa)、等容舒张期左心室压力下降的最大速率(-dp/dt)[分别是(1000±95)、(1 150±100)、(1 110±105)、(1 100±110),(1 050±105)、(1 000±100) mmHg/s]明显低于Ⅰ组(P＜0.05,P＜0.01),Ⅲ组上述参数有所提高,但未恢复到Ⅰ组相应的水平,Ⅳ组可使心肌功能接近Ⅰ组.Ⅱ组的每搏功[分别是(21.2±2.3)、(23.3±2.1)、(27.2±2.3)、(26.3±2.4)、(26.1±3.2)、(25.1±2.3)Q· mm Hg·次-1·min-1]和主动脉峰值收缩压[分别是(55±4)、(54±4)、(56±4)、(55±4)、(53±4)、(53±5) mm Hg]明显低于Ⅰ组(P＜0.05,P＜0.01),Ⅲ组和Ⅳ组与Ⅰ组的差异均无统计学意义.结论严重热伤引起低血容量休克中,输注醋酸钠林格注射液更有利于改善心肌功能及顺应性.
목적 연구불동복소액대열상휴극적가토심기공능적영향.방법40지가토완전수궤분위4조(매조10지):Ⅰ조:대조조(미열상조)；Ⅱ조:0.9％생리염수조；Ⅲ조:유산납림격주사액조；Ⅳ조:작산납림격주사액조.열상체체표면적25％～30％후,액체수주속도이매1％열상면적0.33 ml·kg-1·h-1지속4h.통과제비리체공작심장모형측정각조심기공능.결과 Ⅱ조적심수출량(cardiac output,CO)[분별시(85±9)、(90±9)、(102±11)、(103±10)、(99±10)、(101±11) ml/min]、등용수축기좌심실내압력상승적속솔(dp/dt)[분별시(1 200±110)、(1 350±125)、(1 210±100)、(1 200±115)、(1 150±120)、(1 000±95)mmHg/s](1 mm Hg=0.133 kPa)、등용서장기좌심실압력하강적최대속솔(-dp/dt)[분별시(1000±95)、(1 150±100)、(1 110±105)、(1 100±110),(1 050±105)、(1 000±100) mmHg/s]명현저우Ⅰ조(P＜0.05,P＜0.01),Ⅲ조상술삼수유소제고,단미회복도Ⅰ조상응적수평,Ⅳ조가사심기공능접근Ⅰ조.Ⅱ조적매박공[분별시(21.2±2.3)、(23.3±2.1)、(27.2±2.3)、(26.3±2.4)、(26.1±3.2)、(25.1±2.3)Q· mm Hg·차-1·min-1]화주동맥봉치수축압[분별시(55±4)、(54±4)、(56±4)、(55±4)、(53±4)、(53±5) mm Hg]명현저우Ⅰ조(P＜0.05,P＜0.01),Ⅲ조화Ⅳ조여Ⅰ조적차이균무통계학의의.결론 엄중열상인기저혈용량휴극중,수주작산납림격주사액경유리우개선심기공능급순응성.
Objective To study the effects of different fluids on on cardiac function of rabbits with thermal burn-induced shock Methods 40 rabbits were randomly divided into four groups,group Ⅰ:control group (without thermal injury),group Ⅱ:0.9％ NaC1 solution,group Ⅲ:lactated Ringer's solution,group Ⅳ:acetated Ringer's injection.The infusion rate was 0.33 ml/kg/％(area percentage of heat injury)/h in 4 h when the thermal injury of rabbit body surface area was 25％ to 30％.Cardiac function were measured in each group by working heart preparation in vitro model.Results Cardiac output(CO)[ (85±9),(90±9),(102±11),(103±10),(99±10),(101±11) ml/min],dp/dt[(1 200±110),(1 350±125),(1 210±100),(1 200±115),(1 150±120),(1 000±95) mmHg/s (1 mm Hg=0.133 kPa)],-dp/dt[(1 000±95),(1 150±100),(1 110±105),(1 100±110),(1 050±105),(1 000±100) mm Hg/s]in group Ⅱ were significantly lower than those in group Ⅰ (P＜0.05,P＜0.01 ),and these parameters were improved in group Ⅲ,but could not return to the levels in group.The parameters in group Ⅳ were similar to those in group Ⅰ (P＞0.05).Stroke work [ (21.2±2.3 ),(23.3±2.1),(27.2±2.3),(26.3±2.4),(26.1±3.2),(25.1±2.3) Q·mm Hg·bpm-1] and aortic peak systolic pressure[(55±4),(54±4),(56±4),(55±4),(53±4),(53±5) mm Hg] in group Ⅱ were significantly lower than those of group Ⅰ (P＜0.05,P＜0.01) while these parameters in group Ⅲ and Ⅳ were not different,compared to those of group. Conclusions Compound electrolyte solution infusion can improve cardiac function of rabbits with thermal burn-induced shock.