CAJ | 학술논문

目的　确定在Graves病(GD)多发家系成员中，甲状腺自身免疫及甲状腺功能异常的发生情况，并研究碘摄入量对GD发病率的影响。方法　对全部家系成员做甲状腺疾病病史询问、体格检查、甲状腺功能及甲状腺自身抗体测定，并测定空腹尿碘含量。结果　GD患者一级亲属的亚临床甲亢、临床甲减、亚临床甲减的患病率分别为5.2%、1.0%和1.4%，这三种疾病患者的甲状腺自身抗体均为阳性。甲状腺功能正常一级亲属的甲状腺自身抗体阳性率为68.6%。尿碘水平500～599 μg/L时，GD的发病率显著增高(P＜0.05)。结论　在GD多发家系中，GD患者一级亲属发生甲状腺功能异常的原因均为自身免疫甲状腺病；尿碘水平500～599 μg/L是GD发病率增高的危险因素
목적　학정재Graves병(GD)다발가계성원중，갑상선자신면역급갑상선공능이상적발생정황，병연구전섭입량대GD발병솔적영향。방법　대전부가계성원주갑상선질병병사순문、체격검사、갑상선공능급갑상선자신항체측정，병측정공복뇨전함량。결과　GD환자일급친속적아림상갑항、림상갑감、아림상갑감적환병솔분별위5.2%、1.0%화1.4%，저삼충질병환자적갑상선자신항체균위양성。갑상선공능정상일급친속적갑상선자신항체양성솔위68.6%。뇨전수평500～599 μg/L시，GD적발병솔현저증고(P＜0.05)。결론　재GD다발가계중，GD환자일급친속발생갑상선공능이상적원인균위자신면역갑상선병；뇨전수평500～599 μg/L시GD발병솔증고적위험인소
Objective　To investigate the prevalence of thyroid autoimmunity and thyroid dysfunction in members from multiplex families with Graves' disease (GD), and to evaluate the effect of iodine intake on the incidence of GD. Methods　In addition to history and physical examination, thyroid function, thyroid autoantibodies and fasting urinary iodine were measured for all the subjects. Results　In first-degree relatives of patients with GD, the prevalences of subclinical hyperthyroidism, overt and subclinical hypothyroidism were 5.2%, 1.0% and 1.4% respectively, and thyroid autoantibodies were positive for all these patients. The positive rate of anti-thyroid antibodies was 68.6% in euthyroid first-degree relatives. The incidence of GD increased significantly when the urinary iodine excretion was 500～599 μg/L (P＜0.05). Conclusion　In multiplex families with GD, the pathogenetic causes of all kinds of thyroid dysfunction in first-degree relatives of GD patients are due to autoimmune thyroid diseases. Urinary iodine excretion 500～599 μg/L is a risk factor for higher occurrence of GD