CAJ | 학술논문

目的　了解用门静脉动脉化重建肝血流的可行性。　方法　建立门静脉动脉化重建肝脏血流的梗阻性黄疸大鼠实验模型，观察肝脏的结构和功能改变。　结果　大鼠胆总管结扎5d后，胆红素（BIL）、转氨酶（ALT、AST）和碱性磷酸酶（ALP）显著增高（与对照组相比，P<0.01），胆总管结扎5d后的大鼠行胆管再通+门静脉动脉化手术后1周，BIL即可恢复正常（与对照组相比，P＞0.05），ALT、AST和ALP明显下降，但差异仍有显著意义（P＜0.05）,手术后1个月即可完全恢复正常（与对照组相比，P＞0.05），肝脏结构亦可顺利恢复。　结论　门静脉动脉化重建肝血流在临床上有一定的可行性和应用前景
목적　료해용문정맥동맥화중건간혈류적가행성。　방법　건립문정맥동맥화중건간장혈류적경조성황달대서실험모형，관찰간장적결구화공능개변。　결과　대서담총관결찰5d후，담홍소（BIL）、전안매（ALT、AST）화감성린산매（ALP）현저증고（여대조조상비，P<0.01），담총관결찰5d후적대서행담관재통+문정맥동맥화수술후1주，BIL즉가회복정상（여대조조상비，P＞0.05），ALT、AST화ALP명현하강，단차이잉유현저의의（P＜0.05）,수술후1개월즉가완전회복정상（여대조조상비，P＞0.05），간장결구역가순리회복。　결론　문정맥동맥화중건간혈류재림상상유일정적가행성화응용전경
Objective　 In cases of proximal bile duct cancer, radical en bloc resection of the hepatodudenal ligament is sometimes compulsory.This study was undertaken to evaluate the feasibility of arterialization of the portal vein to restore liver blood flow after the radical resection.　Methods 　Experimental model was established in rats with common bile duct ligation. Operative effect on rats was viewed and alterations of liver function and structure was investigated.　 Results　 BIL,ALT,AST and ALP elevated significantly (compared with normal, P＜0.01) on 6 days after common bile duct ligation. BIL became normal (P＞0.05),ALT,AST and ALP fell obviously,but still had significant difference compared with normal (P＜0.05) at one week after bile duct reopening plus arterialization of portal vein, ALT, AST and ALP become normal （compared with normal, P＞0.05） in one month. Liver structure recovered smoothly.　Conclusions　 The method of reconstruction after resection of the hepatodudenal ligament may be applicable for clinical use.