CAJ | 학술논문

被分析组分的光谱净信号将正交于其它药物组分和辅料光谱所张成的光谱子空间,从而消除其它组分对被分析组分的光谱干扰,此净信号将与被分析组分的浓度成正比,据此建立了药物制剂分析的净信号方法.本文利用该方法研究了在酸性条件下紫外光谱测定复方磺胺甲噁唑片的两种有效成分磺胺甲噁唑(SMZ)和甲氧苄啶(TMP).SMZ和TMP的线性范围分别为0.48-7.84μg/mL(r=0.9981)和0.12-1.5μg/mL(r=0.9986),平均回收率分别为99.5%和101.0%,RSD分别为1.87%和3.60%.本法简便、快速和准确,可用于酸性条件下复方磺胺甲噁唑片中SMZ和TMP含量的快速、同时准确测定.
피분석조분적광보정신호장정교우기타약물조분화보료광보소장성적광보자공간,종이소제기타조분대피분석조분적광보간우,차정신호장여피분석조분적농도성정비,거차건립료약물제제분석적정신호방법.본문이용해방법연구료재산성조건하자외광보측정복방광알갑오서편적량충유효성분광알갑오서(SMZ)화갑양변정(TMP).SMZ화TMP적선성범위분별위0.48-7.84μg/mL(r=0.9981)화0.12-1.5μg/mL(r=0.9986),평균회수솔분별위99.5%화101.0%,RSD분별위1.87%화3.60%.본법간편、쾌속화준학,가용우산성조건하복방광알갑오서편중SMZ화TMP함량적쾌속、동시준학측정.
Since the spectral net signal of the analyzed component was orthogonal to the spectral subspace spanned by the other drug spectra and the assistant ones,the spectral disturbance of the analyzed component should be eliminated,and then its spectral net signal should be directly proportional to its concentration.Based on the basic idea,the analyzed component of the drug was determined.This paper has studied the determinations of the two effective components sulfamethoxazole(SMZ)and trimethoprim (TMP)contained in compound sulfamethoxazole tablet by using ultraviolet spectroscopy.The linear ranges of SMZ and TMP were 0.48-7.84(g/mL(r=0.9981) and 0.12-1.5μg/mL(r=0.9986),the corresponding average recoveries were 99.5% and 101.0%,and the relative standard deviations were 1.87% and 3.60%,respectively.The method was simple,fast and accurate.It could be used in acid condition to simultaneously determine SMZ and TMP in the compound sulfamethoxazole tablet.