CAJ | 학술논문

在Span80与植物油形成的反相胶束体系中,通过戊二醛交联制备出壳聚糖水凝胶微球(CHM).采用红外光谱和透射电镜等方法对CHM结构及粒子形态进行了研究.同时对CHM的溶胀度及其对模型药物双氯灭痛的体外释放行为进行了考察.结果表明,CHM具有较好的控制药物释放的作用.交联程度对微球粒径、溶胀度及药物释放性能影响较大.
재Span80여식물유형성적반상효속체계중,통과무이철교련제비출각취당수응효미구(CHM).채용홍외광보화투사전경등방법대CHM결구급입자형태진행료연구.동시대CHM적용창도급기대모형약물쌍록멸통적체외석방행위진행료고찰.결과표명,CHM구유교호적공제약물석방적작용.교련정도대미구립경、용창도급약물석방성능영향교대.
Chitosan hydrogel microspheres (CHM) cross-linked with glutaraldehyde have been prepared in Span80/soja salad oil reverse micellar system.The structural characterization and the shape of the cross-linked CHM were studied by TEM and IR methods.Additional,the swelling degree of CHM and the release behavior of voltraren loaded in CHM in vitro were also studied.The results show CHM shows the satisfying function of controlling drug release.The diameter,the swelling degree and the capability of loading drug and controlling release of CHM depend largely on the cross-linking degree.