CAJ | 학술논문

目的　探讨凋亡相关基因产物Fas和FasL 蛋白在肾癌发生中的作用以及与转移、预后的关系。方法　采用免疫组织化学方法对46例肾癌组织和15例正常肾组织Fas和FasL蛋白的表达进行检测。结果　肾癌组织Fas表达率为18.14%，低于正常肾组织（46.15%，P<0.05），随肾癌分级的增加，表达强度下降。肾癌组织FasL蛋白表达率为70.26%，高于正常肾组织（10.32%，P<0.05），随肾癌分级的增加，表达强度增高。正常肾组织Fas与FasL的表达有相关性（r=0.689，P<0.05），肾癌组织无相关性（r=0.143，P>0.05），有淋巴结转移组FasL(89.42%)与无淋巴结转移组(60.39%)比较，差别有显著性意义(P<0.01)。生存率>5年组Fas(25.39%)和FasL(61.26%)与生存率<5年组Fas(15.24%)和FasL(85.35%)的差别均有显著性意义(P均<0.05)。结论　Fas和FasL蛋白相互作用失衡在肾癌的发生、发展中起重要作用，表达情况与肾癌病理分级及转移、预后有一定关系。
목적　탐토조망상관기인산물Fas화FasL 단백재신암발생중적작용이급여전이、예후적관계。방법　채용면역조직화학방법대46례신암조직화15례정상신조직Fas화FasL단백적표체진행검측。결과　신암조직Fas표체솔위18.14%，저우정상신조직（46.15%，P<0.05），수신암분급적증가，표체강도하강。신암조직FasL단백표체솔위70.26%，고우정상신조직（10.32%，P<0.05），수신암분급적증가，표체강도증고。정상신조직Fas여FasL적표체유상관성（r=0.689，P<0.05），신암조직무상관성（r=0.143，P>0.05），유림파결전이조FasL(89.42%)여무림파결전이조(60.39%)비교，차별유현저성의의(P<0.01)。생존솔>5년조Fas(25.39%)화FasL(61.26%)여생존솔<5년조Fas(15.24%)화FasL(85.35%)적차별균유현저성의의(P균<0.05)。결론　Fas화FasL단백상호작용실형재신암적발생、발전중기중요작용，표체정황여신암병리분급급전이、예후유일정관계。
Objective　To detect and evaluate the expression of Fas and FasL in renal cell carcinomas.Methods　Fas and FasL expressions were assayed by means of immunohistochemical SP technique in 46 cases of renal cell carcinomas and in 15 cases of controlled normal kidney tissues.Results　Fas expression rate in renal cell carcinomas was lower than in the expression in the controlled normal kidney tissues （P<0.05）,but FasL expression rate in renal cell carcinoma was higher than in controlled normal kidney tissues（P<0.05）.The expression of Fas and FasL had a correlation in normal kidney tissues （r=0.689,P<0.05）, but not in renal cell carcinomas（r=0.143）. The expression of FasL between lymph node involved group and lymph node uninvolved group, more than 5 year survival group and less than 5 year group was significantly different.Conclusions　Dysfunction of the interaction between Fas and FasL might contribute to malignant transformation of renal cell carcinomas. FasL had some relation with tumor metastasis.Fas and FasL expressions might serve as a prognostic factor of renal cell carcinomas.