CAJ | 학술논문

目的：探讨高原性慢性肺心病呼吸指数(RI)变化与病情严重程度的关系及判断预后的意义。方法：188例高原慢性肺心病急性加重期患者测定了肺泡气氧分压(PAO2)和动脉血气，计算RI，RI＝PAO2 －PaO2／PaCO2，并与36例当地健康人比较。结果：肺心病无呼衰(NRF)、轻度呼衰(LRF)、中度呼衰(MRF)、重度呼衰(SRF)组PaO2显著低于对照组，A－aDO2和RI显著高于对照组，肺心病各组之间比较也有显著性差异，P均＜0. 01。肺心病各组治疗后较治疗前均显著改善(P＜0.01)。RI与PaO2、PAO2呈显著负相关(r＝－0.968、－0.526，P＜0.01)；与PaCO2、A－aDO2呈显著正相关(r ＝0.697、0.927，P＜0.01)。结论：高原肺心病RI 变化与呼衰的严重程度一致，RI可作为判断高原肺心病呼衰程度、病情监测和预后的指标之一。
목적：탐토고원성만성폐심병호흡지수(RI)변화여 병 정엄중정도적관계급판단예후적의의。방법：188례고원 만성폐심병급성가중기환자측정료폐포기양분압(PAO2)화동맥혈기，계산RI，RI＝PAO2 －PaO2／PaCO2，병여36례당지건강인비교。결과：폐심병무호쇠(NRF)、경도호쇠(LRF)、중도호쇠(MRF)、중도호쇠(SRF)조PaO2현저저우대 조조，A－aDO2화RI현저고우대조조，폐심병각조지간비교야유현저성차이，P균＜0. 01。폐심병각조치료후교치료전균현저개선(P＜0.01)。RI여PaO2、PAO2정현저부 상관(r＝－0.968、－0.526，P＜0.01)；여PaCO2、A－aDO2정현저정상관(r ＝0.697、0.927，P＜0.01)。결론：고원폐심병RI 변화여호쇠적엄중정도일치，RI가작위판단고원폐심병호쇠정도、병정감측화예후적지표지일。
Objective:To study the changes and the clin ical significance of respiratory index(RI)in chronic pulmonary heart disease(CCP ) at high altitude．Methods:Alveolar PO2(PAO2) a nd arterial blood gas were measured in 188 cases of CCP in exacerbation stage an d 36 health persons at 2 260－3 300 m altitude.The CCP group was divided upon no rma l respiratory function(NRF),light respiratory failure(LRF),moderate respiratory failure (MRF) and severe respiratory failure(SRF)subgroup.Results: PaO2 level was significantly lower in CCP group than that in con trol group and the levels of A-aDO2 and RI were higher in CCP group than those in control group.The difference of PaO2，A-aDO2 and RI levels between eac h subgroup and another were significant.The differences of these indexes between in before and after treatment wree significant(P＜0.01).The level of RI was significantly negatively correlated with those of PaO2，PAO2 and positi ve correlated with those of PaCO2 and A-aDO2.Conclusion:The change of RI is significantly correlated with the degree of RF.RI is helpful for evaluating the RF and prognosis in CCP at high altitude.