CAJ | 학술논문

鼻咽癌是中国人,特别是中国南方人的一种常见癌症;世界上除其他少数族群具有中等程度的发病率以外,它是一种罕见的癌症.鼻咽癌多见于男性,男女发病率之比约为3:1,且好发于中年人.现今已有令人信服的证据,支持EB病毒(国际癌症研究协会归属为第一类人体肿瘤病毒)是鼻咽癌的致病因子,肯定参与鼻咽癌的多阶段、多因素发生过程.本文简要地复阅了EB病毒在鼻咽癌发病机理中的作用,重点地介绍了EB病毒抗体和EB病毒DNA作为鼻咽癌标志的主要应用;根据由鼻咽癌导致的EB病毒抗体反应的现代知识,并考虑到目前可采用的检测技术,提出了促进有效地早期发现鼻咽癌的血清学筛选策略.
비인암시중국인,특별시중국남방인적일충상견암증;세계상제기타소수족군구유중등정도적발병솔이외,타시일충한견적암증.비인암다견우남성,남녀발병솔지비약위3:1,차호발우중년인.현금이유령인신복적증거,지지EB병독(국제암증연구협회귀속위제일류인체종류병독)시비인암적치병인자,긍정삼여비인암적다계단、다인소발생과정.본문간요지복열료EB병독재비인암발병궤리중적작용,중점지개소료EB병독항체화EB병독DNA작위비인암표지적주요응용;근거유비인암도치적EB병독항체반응적현대지식,병고필도목전가채용적검측기술,제출료촉진유효지조기발현비인암적혈청학사선책략.
Nasopharyngeal carcinoma (NPC) is a common canceramong Chinese, especially Southern Chinese; except for a few other ethnic groups with moderate incidence, it is otherwise a rare cancer in the world.NPC has a male dominance of about 3:1 and mainly afflicts people in midlife. There is now compelling evidences to suggest that Epstein-Barr virus (EBV), a category Ⅰ human tumor virus defined by UICC (International Agency for Research on Cancer) in 1997, is a causal agent of NPC and is most likely to be involved in the multi-step and multi-factorial development of NPC. In this article, the role of EBV in pathogenesis of NPC is reviewed briefly, and principle applications of EBV antibodies and EBV DNA as markers of NPC are outlined. Based on current knowledge of EBV antibody responses by NPC and taking available testing technologies into account,serologic screening strategy to facilitate efficient early detection of NPC is formulated.