中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2013年
21期
107-108,109
,共3页
脑胶质瘤%放射治疗%替莫唑胺
腦膠質瘤%放射治療%替莫唑胺
뇌효질류%방사치료%체막서알
Brain glioma%Radiotherapy%Temozolomide
目的：探讨脑胶质瘤术后放射治疗联合替莫唑胺化疗的治疗效果。方法：选取2008年1月-2010年12月本院收治的WHOⅢ~Ⅳ级脑胶质瘤患者54例，随机分为A组和B组各27例，两组均在手术切除肿瘤后给予放射治疗，B组进行放射治疗，A组在放射治疗的基础上使用替莫唑胺化疗。对比两组的近期疗效、生存率和不良反应。结果：A组有效率为77.8%；高于B组的48.1%，比较差异有统计学意义（P<0.05）；两组的1年生存率比较差异无统计学意义（P>0.05），A组的2年生存率为48.1%，高于B组的22.2%，比较差异有统计学意义（P<0.05）。A组的不良反应与B组比较，差异无统计学意义（P>0.05）。结论：脑胶质瘤术后联合放化疗能有效提高治疗效果，延长患者的生存期，值得推广应用。
目的：探討腦膠質瘤術後放射治療聯閤替莫唑胺化療的治療效果。方法：選取2008年1月-2010年12月本院收治的WHOⅢ~Ⅳ級腦膠質瘤患者54例，隨機分為A組和B組各27例，兩組均在手術切除腫瘤後給予放射治療，B組進行放射治療，A組在放射治療的基礎上使用替莫唑胺化療。對比兩組的近期療效、生存率和不良反應。結果：A組有效率為77.8%；高于B組的48.1%，比較差異有統計學意義（P<0.05）；兩組的1年生存率比較差異無統計學意義（P>0.05），A組的2年生存率為48.1%，高于B組的22.2%，比較差異有統計學意義（P<0.05）。A組的不良反應與B組比較，差異無統計學意義（P>0.05）。結論：腦膠質瘤術後聯閤放化療能有效提高治療效果，延長患者的生存期，值得推廣應用。
목적：탐토뇌효질류술후방사치료연합체막서알화료적치료효과。방법：선취2008년1월-2010년12월본원수치적WHOⅢ~Ⅳ급뇌효질류환자54례，수궤분위A조화B조각27례，량조균재수술절제종류후급여방사치료，B조진행방사치료，A조재방사치료적기출상사용체막서알화료。대비량조적근기료효、생존솔화불량반응。결과：A조유효솔위77.8%；고우B조적48.1%，비교차이유통계학의의（P<0.05）；량조적1년생존솔비교차이무통계학의의（P>0.05），A조적2년생존솔위48.1%，고우B조적22.2%，비교차이유통계학의의（P<0.05）。A조적불량반응여B조비교，차이무통계학의의（P>0.05）。결론：뇌효질류술후연합방화료능유효제고치료효과，연장환자적생존기，치득추엄응용。
Objective:To explore the therapeutic efficacy of brain glioma treated with postoperative radiotherapy combined with temozolomide chemotherapy.Method:54 patients with WHO gradeⅢ-Ⅳgliomas from January 2008 to December 2010 were divided into group A and group B,with 27 patients in each group.Both groups were given radiotherapy after surgical resection of the tumor.Group B was given radiotherapy,group A was given temozolomide chemotherapy on the basis of radiotherapy.The short-term effect,survival and adverse reactions of two groups were compared.Result:The effective rate of group A(77.8%)was higher than that of group B(48.1%).The difference was statistically significant between the two groups(P<0.05). The one-year survival rates of the two groups showed no significant difference(P>0.05).The two-year survival rate of group A was 48.1%,which was higher than the 22.2%of group B,the difference was statistically significant(P<0.05).Compared the adverse reactions of group A with group B,the difference was not statistically significant(P>0.05).Conclusion:Postoperative radiotherapy combined with chemotherapy treating glioma can effectively improve the therapeutic effect and prolong the survival,should be widely applied.
