CAJ | 학술논문

目的：研究扶正抗白冲剂(FZKBG)对实验小鼠免疫功能及生存期的影响，探讨FZKBG治疗微小残留白血病(MRL)的机理。方法：接种L7212细胞1×106／只，接种后第3天腹腔注射环磷酰胺250mg/kg，造成MRL模型小鼠，分成模型对照组、模型给药组，另设正常对照组、正常给药组，分别观察各组小鼠淋巴细胞亚群(CD3+、CD4+、CD8+)改变，免疫器官病理变化和生存期。结果：与模型组比较，FZKBG能明显提高正常小鼠和MRL模型小鼠CD3+、CD4+、CD8+的百分比和绝对值(P＜0.05，P＜0.01)。且明显延长MRL模型小鼠存活期，延长生命率29.6%～60.4%。结论：FZKBG能明显延长MRL模型小鼠存活期，其机理可能是通过提高MRL模型小鼠的免疫功能，抑制体内白血病细胞而实现的。
목적：연구부정항백충제(FZKBG)대실험소서면역공능급생존기적영향，탐토FZKBG치료미소잔류백혈병(MRL)적궤리。방법：접충L7212세포1×106／지，접충후제3천복강주사배린선알250mg/kg，조성MRL모형소서，분성모형대조조、모형급약조，령설정상대조조、정상급약조，분별관찰각조소서림파세포아군(CD3+、CD4+、CD8+)개변，면역기관병리변화화생존기。결과：여모형조비교，FZKBG능명현제고정상소서화MRL모형소서CD3+、CD4+、CD8+적백분비화절대치(P＜0.05，P＜0.01)。차명현연장MRL모형소서존활기，연장생명솔29.6%～60.4%。결론：FZKBG능명현연장MRL모형소서존활기，기궤리가능시통과제고MRL모형소서적면역공능，억제체내백혈병세포이실현적。
Objective: To observe the effects of Fuzheng Kangbai Granule(FZKBG) on immune function and survival time in minimal residual leukemia (MRL) model mice and study its mechanism. Methods: MRL model mice were established by hypodermic inoculation with L7212 cells following intraperitoneal injection of cytoxan (CTX)25 mg/kg 3 days later, and divided into the control group and FZKBG group. The changes of T-lymphocyte subsets, including CD3＋、CD4＋ and CD8＋, and the survival time in model mice were observed. Results: Comparing with the control group, FZKBG could obviously increase both the percentage and absolute value of CD3＋and CD4＋ lymphocytes and prolong the survival time of model mice, the prolongation rate being 29.6%－60.4%. Conclusion: FZKBG could markedly prolong the survival time of MRL mice, its mechanism might be through elevating the immune function and inhibiting the leukemic cells in model mice.