CAJ | 학술논문

目的　评价双膦酸盐Alendronate抑制牙槽骨骨吸收的作用。方法　建立骨质疏松及牙槽骨吸收动物模型，建模术后六周，给实验组皮下注射Alendronate每周3次，共6周；用血生化指标骨生物力学、骨密度测量、组织形态学等方法进行药效评价。结果　股骨骨密度对照组与用药组相比明显降低(P＜0.01)；血清碱性磷酸酶对照组与用药组相比明显升高(P＜0.01)；骨生物力学各项指标实验组与对照组也有明显差异。组织形态学：实验组牙龈轻度炎症，牙槽骨水平吸收与对照组相比明显减少；对照组牙龈乳突炎症明显，上皮钉突增生，炎细胞浸润，牙槽骨明显水平吸收。结论　Alendron ate治疗骨质疏松有明显的疗效，能够增加骨量，阻止骨丢失；对病理性牙槽骨骨吸收有显著的治疗作用。
목적　평개쌍련산염Alendronate억제아조골골흡수적작용。방법　건립골질소송급아조골흡수동물모형，건모술후륙주，급실험조피하주사Alendronate매주3차，공6주；용혈생화지표골생물역학、골밀도측량、조직형태학등방법진행약효평개。결과　고골골밀도대조 조여용약조상비명현강저(P＜0.01)；혈청감성린산매대조조여용약조상비명현승 고(P＜0.01)；골생물역학각항지표실험조여대조조야유명현차이。조직형태학： 실험조아간경도염증，아조골수평흡수여대조조상비명현감소；대조조아간유돌염증명현， 상피정돌증생，염세포침윤，아조골명현수평흡수。결론　Alendron ate치료골질소송유명현적료효，능구증가골량，조지골주실；대병이성아조골골흡수유현저적치료작용。
Objective．Osteoporosis and periodontal disease animal models were used to evaluate the anti-resorption effect of alendr onate on bone.Methods．To establish osteoporosis and alveo lar bone resorption animal models.The experimental groups (ovariectomized dental ligature group and simple dental ligature group) were given alendronate in 0. 5mg/kg BW by subcutaneous injection after six weeks of ovariectomy and dental ligature,three times a week for 6 weeks.All the animals were sacrifised 12 weeks after the operation.The blood samples were collected for determination of bioch emical indexes.The left femora and jaw bone were processed for histomorphometry. The right femora and mendibles were prepared for determination of bone density and bone biodynamics.Results．As compared with the control groups (without alendronate),the values of experimental groups (with alendronate ) were all significantly improved on bone density and bone anti-curve power.The alkaline phosphatase,calcium in serum of ovariectomy groups (without alendronate ) were obviously increased.In the alendronate group,however,these indexes werec lose to normal levels.In histomorphometry,there were little inflammation in gingiva and less level alveolar bone resorption in the experimental groups;but there was obvious gingivitis and level alveolar bone resorption in the control groups .Conclusion．Alendronate can effectively treat osteoporosis,increase bone volume and prevent bone lose in ovariectomized female rats and inhibit pathological alveolar bone resorption.