CAJ | 학술논문

应用反相高效液相色谱法测试了6只健康绒山羊以每千克体重100 mg剂量口服给药后吡喹酮在体内的血药浓度，并进行了药代动力学研究，应用非线性最小二乘法处理，实验数据参数用一室模型描述。在口服给药后，经过短暂的迟滞期［Lagtime=（0.23987±0.09539）h］，血药浓度迅速上升，吸收相很快完成［t1/2ka=（0.33899±0.19294）h］，达峰时间tp=（1.64568±0.43788）h，之后是一缓慢的消除相［t1/2kel=（6.23789±0.70627）h］，表观分布容积Vd=（23.68130±13.16197）L／kg，机体清除率CLB=［（2.62346±1.47310）mg/（kg*h）］，药时曲线下面积AUC=［（50.07327±26.12482）μg/（mL*h）］，最高血药浓度Cmax=（4.89990±2.83064）μg／mL。对吡喹酮在绒山羊体内血药浓度实测值与理论值进行卡平方检验，结果表明二者之间没有显著性差异（P＞0.05）。
응용반상고효액상색보법측시료6지건강융산양이매천극체중100 mg제량구복급약후필규동재체내적혈약농도，병진행료약대동역학연구，응용비선성최소이승법처리，실험수거삼수용일실모형묘술。재구복급약후，경과단잠적지체기［Lagtime=（0.23987±0.09539）h］，혈약농도신속상승，흡수상흔쾌완성［t1/2ka=（0.33899±0.19294）h］，체봉시간tp=（1.64568±0.43788）h，지후시일완만적소제상［t1/2kel=（6.23789±0.70627）h］，표관분포용적Vd=（23.68130±13.16197）L／kg，궤체청제솔CLB=［（2.62346±1.47310）mg/（kg*h）］，약시곡선하면적AUC=［（50.07327±26.12482）μg/（mL*h）］，최고혈약농도Cmax=（4.89990±2.83064）μg／mL。대필규동재융산양체내혈약농도실측치여이론치진행잡평방검험，결과표명이자지간몰유현저성차이（P＞0.05）。
The drug concentration of plaziquantel in plasma were determined by high performance liquid chromatography（HPLC）and the pharmacokinetics of praziquantel were determined after oral administration of 100　mg/kg of body weight to six cashmere goats using nonlinear least squares regression methods．Data obtained were best described by one compartment open model．After dosing there is a short lagtime ［Lagtime=（0.23987±0.09539）h］．Then plasma concentration of praziguantel increased rapidly. And the absorption phase was quickly completed ［t1/2ka=（0.33899±0.19294）h］．The time of peak (tp) is described as tp=（1.64568±0.43788）h．After peak, there is long clearance phase ［t1/2kel=（6.23789±0.70627）h］．The apparent volume of distribution Vd=（23.68130±13.16197）L／kg．The mean body clearance rate　CLB=［（2.62346±1.47310）mg/（kg*h）］．The area under curve of concentration time AUC=［（50.07321±26.12482）μg/（mL*h）］．The maximal plasma concentration Cmax=（4.89990±2.83064）μg／mL． No significant difference was found between the measured values and theoretically predicted values in the plasma concentration of praziquantel (P>0.05)．