湖南医科大学学报
湖南醫科大學學報
호남의과대학학보
BULLETIN OF HUNAN MEDICAL UNIVERSITY
2001年
2期
167-168
,共2页
唐正严%易红%谌兵来%齐范%张时纯
唐正嚴%易紅%諶兵來%齊範%張時純
당정엄%역홍%심병래%제범%장시순
膀胱肿瘤%端粒酶%多聚酶链反应%方法
膀胱腫瘤%耑粒酶%多聚酶鏈反應%方法
방광종류%단립매%다취매련반응%방법
目的:探讨端粒酶活性与膀胱癌之间的关系。方法:采用Telomerase PCR ELISA法对41例膀胱癌组织和23例非癌患者膀胱组织中端粒酶活性进行检测。结果:41例膀胱癌组织中端粒酶阳性34例,阳性率82.9%,23例非癌患者膀胱组织中端粒酶阳性1例,阳性率4.3%。两组端粒酶活性比较,阳性率差异有显著性(P<0.01)。结论:端粒酶活性与膀胱癌之间密切相关,端粒酶活化可能是膀胱癌发生及发展过程中的重要分子事件。端粒酶可作为早期发现膀胱癌、术后随诊的分子生物学标记。
目的:探討耑粒酶活性與膀胱癌之間的關繫。方法:採用Telomerase PCR ELISA法對41例膀胱癌組織和23例非癌患者膀胱組織中耑粒酶活性進行檢測。結果:41例膀胱癌組織中耑粒酶暘性34例,暘性率82.9%,23例非癌患者膀胱組織中耑粒酶暘性1例,暘性率4.3%。兩組耑粒酶活性比較,暘性率差異有顯著性(P<0.01)。結論:耑粒酶活性與膀胱癌之間密切相關,耑粒酶活化可能是膀胱癌髮生及髮展過程中的重要分子事件。耑粒酶可作為早期髮現膀胱癌、術後隨診的分子生物學標記。
목적:탐토단립매활성여방광암지간적관계。방법:채용Telomerase PCR ELISA법대41례방광암조직화23례비암환자방광조직중단립매활성진행검측。결과:41례방광암조직중단립매양성34례,양성솔82.9%,23례비암환자방광조직중단립매양성1례,양성솔4.3%。량조단립매활성비교,양성솔차이유현저성(P<0.01)。결론:단립매활성여방광암지간밀절상관,단립매활화가능시방광암발생급발전과정중적중요분자사건。단립매가작위조기발현방광암、술후수진적분자생물학표기。
Objective To study the correlation between telomerase and bladder cancer. Methods The telomerase activity was detected by telomerase PCR ELISA in 41 cases of bladder cancer tissues and 23 cases of non-cancerous bladder tissues. Results The telomerase activity was positive in 34 cases of bladder cancer tissues (82.9%) and 1 case of non-cancerous tissues (4.3%); the difference of positive rate was significant (P<0.01). Conclusions Telomerase activity is related with bladder cancer closely; telomerase activation may be an impotant molecular step in the initiation and development of bladder cancer; telomerase may be an excellent molecular biomarker in finding bladder cancer at an early stage and in postoperative following-up.