CAJ | 학술논문

目的：比较两种途径输注前列腺素E1对肝缺血再灌注损伤的保护作用，寻找最佳途径。方法：20只SD大鼠随机分为两组，在行肝左叶血流阻断及解除阻断同时，门静脉组经门静脉输注PG E1；外周组经股静脉输注PG E1。测定肝血流阻断45 min 再灌注1 h 后各组的ALT、AST、LDH值，观察缺血肝叶光镜、电镜下的病理变化及干、湿重量比。结果：门静脉组能明显改善肝功能，与外周静脉组比较有显著差异。外周静脉组缺血肝叶病理学检查见肝细胞呈点片状水肿，核膜有变形；门静脉组肝组织损害不明显。结论：经门静脉输注PG E1是一种新的、安全的对常温下肝缺血再灌注损伤的有效保护方法。
목적：비교량충도경수주전렬선소E1대간결혈재관주손상적보호작용，심조최가도경。방법：20지SD대서수궤분위량조，재행간좌협혈류조단급해제조단동시，문정맥조경문정맥수주PG E1；외주조경고정맥수주PG E1。측정간혈류조단45 min 재관주1 h 후각조적ALT、AST、LDH치，관찰결혈간협광경、전경하적병리변화급간、습중량비。결과：문정맥조능명현개선간공능，여외주정맥조비교유현저차이。외주정맥조결혈간협병이학검사견간세포정점편상수종，핵막유변형；문정맥조간조직손해불명현。결론：경문정맥수주PG E1시일충신적、안전적대상온하간결혈재관주손상적유효보호방법。
To evaluate the protective effect of PG E1 administered via portal vein through peripheral venous.Methods:20 SD rats were divided into two groups.The portal vein treat ment group and the peripheral venous treat group were administered with PG E1(30 μg/kg) before ischemia and reperfusion.The liver functions of rats were tested.The dry weight and wet weight of liver and histological exam after 45 minutes ischemia and 1 hour reperfusion were recored.Results:Liver functions as expressed by serum ALT、AST、LDH were significantly drecreased in portal vein group compared with peripheral venous group.The patology of ischemia liver in peripheral venous group was more serious than that in portal vein group.Conclusion:PG E1 through portal vein administered can provide effective protection against liver warm ischemia reperfusion injury in rats.