CAJ | 학술논문

目的研究脑卒中时血清神经元特异性烯醇化酶（NSE）的变化及与神经功能缺损的关系。方法脑出血46例，脑梗死69例，正常对照21例。患者分别在起病3d内及2周时采集血标本。血清NSE测定采用酶联免疫分析方法，神经功能缺损评定按斯堪的纳维亚卒中量表（SSS）标准进行。结果脑梗死、脑出血组3d内及起病2周时血清NSE明显高于正常对照组（均为P<0.001)，并与SSS呈明显正相关(P<0.001)。结论脑卒中早期血清NSE明显升高，血清NSE与SSS之间有明显相关性。
목적 연구뇌졸중시혈청신경원특이성희순화매（NSE）적변화급여신경공능결손적관계。방법 뇌출혈46례，뇌경사69례，정상대조21례。환자분별재기병3d내급2주시채집혈표본。혈청NSE측정채용매련면역분석방법，신경공능결손평정안사감적납유아졸중량표（SSS）표준진행。결과 뇌경사、뇌출혈조3d내급기병2주시혈청NSE명현고우정상대조조（균위P<0.001)，병여SSS정명현정상관(P<0.001)。결론 뇌졸중조기혈청NSE명현승고，혈청NSE여SSS지간유명현상관성。
Objective To investigate serum levels of neuron-specific enolase(NSE) and its clinical significance in the patients with cerebral haemorrhage and infarction, and confirm the correlation between the physical disabilities and serum levels of neuron-specific enolase. Methods Forty-six cases with cerebral haemorrhage , sixty-nine caces with cerebral infarctions and twenty-one healthy control caces were included. Blood samples of the patients were taken at 3rd day and 14th day after the event of stroke respectively. Serum levels of NSE were detected with ELISA. Physical disabilities were evaluated with Scandinavian Stroke Scale(SSS). Results NES serum levels at 3rd day in the patients with stroke are significantly higher than that of controls（P<0.001） and on 14th day in the same group of patients（P<0.001）. A significant positive relationship between NSE serum levels on 3rd day and the SSS value of physical disabilities were observed. Conclusions NES serum levels are increased in the early stage of stroke and there is a positive relationship between NSE serum level and SSS value of physical disabilities.