CAJ | 학술논문

目的研究胃癌组织中组织蛋白酶B的表达及探讨组织蛋白酶B表达与胃癌预后指标(肿瘤组织学类型，TNM分期)的关系。方法应用免疫组织化学方法研究54例胃腺癌标本中组织蛋白酶B的表达。结果周围正常胃粘膜上皮组织蛋白酶B阳性率为5.6％(3／54)，胃癌组织中的阳性率为61.1％(33／54)，较周围正常胃粘膜上皮明显升高(P＜0.01)。组织蛋白酶B的表达与胃癌预后指标(肿瘤组织学类型，TNM分期)无明显相关性。结论人胃癌组织中组织蛋白酶B的表达明显升高。
목적연구위암조직중조직단백매B적표체급탐토조직단백매B표체여위암예후지표(종류조직학류형，TNM분기)적관계。방법응용면역조직화학방법연구54례위선암표본중조직단백매B적표체。결과주위정상위점막상피조직단백매B양성솔위5.6％(3／54)，위암조직중적양성솔위61.1％(33／54)，교주위정상위점막상피명현승고(P＜0.01)。조직단백매B적표체여위암예후지표(종류조직학류형，TNM분기)무명현상관성。결론인위암조직중조직단백매B적표체명현승고。
Objective To study the expression of cathepsin B in gastric carcinoma and its relationship with the prognostic indexes (tumor histologic types,TNM stages) of gastric carcinoma.Methods Cathepsin B expression in 54 specimens of human gastric adenocarcinoma was detected and studied by immunohistochemistry.Results Positive rate of cathepsin B in the epithelial tissue of normal gastric mucosa was S.6% (3/54),while positive rate of cathepsin B in the specimens of human gastric carcinoma was 61.1% (33/54),which showed an obvious increasing by comparison (P＜0.01 ).There was no obvious correlation between the expression of cathepsin B and the prognostic indexes of gastric carcinoma such as tumor histologic types and TNM stages.Conclusion the expression of cathepsin B in human gastric adenocarcinoma shows an obvious increasing tendency.