CAJ | 학술논문

为探讨层粘连蛋白(LM)及纤维粘连蛋白(FN)在米非司酮药物流产(以下简称药流)后子宫持续出血时的表达，对20例米非司酮+米索前列醇药物流产后子宫出血(出血组)的刮出组织及10例人工流产负压吸宫术吸出的组织(对照组)，用HE及免疫组织化学方法染色并观察标本。结果：出血组的刮出组织中45%可见滋养细胞或绒毛，90%发现蜕膜组织。2组蜕膜组织的血管及腺上皮基膜、蜕膜细胞周围和一部分蜕膜细胞胞质内都含有较丰富的LM与FN，并且2组间比较，FN与LM含量表达无明显差异(P>0.05)。说明残留蜕膜中含有能分泌大量LM与FN的蜕膜细胞和血管，致使蜕膜组织与子宫壁牢固地结合而不易脱落，影响内膜发育而引起出血。
위탐토층점련단백(LM)급섬유점련단백(FN)재미비사동약물유산(이하간칭약류)후자궁지속출혈시적표체，대20례미비사동+미색전렬순약물유산후자궁출혈(출혈조)적괄출조직급10례인공유산부압흡궁술흡출적조직(대조조)，용HE급면역조직화학방법염색병관찰표본。결과：출혈조적괄출조직중45%가견자양세포혹융모，90%발현세막조직。2조세막조직적혈관급선상피기막、세막세포주위화일부분세막세포포질내도함유교봉부적LM여FN，병차2조간비교，FN여LM함량표체무명현차이(P>0.05)。설명잔류세막중함유능분비대량LM여FN적세막세포화혈관，치사세막조직여자궁벽뢰고지결합이불역탈락，영향내막발육이인기출혈。
To investigate the expression of fibronectin(FN) and laminin(LN)in prolonged uterine bleeding after mifepristone induced abortion, 20 specimens from curettage were obtained from 20 women who had prolonged uterine bleeding after termination of early pregnancy by mifepristone and misoprostol. Ten specimens from normal early pregnancy by suction aspiration served as control group. All samples were studied by immunochemical stainning. Trophoblasts or villi were presented in 45% of the cases with prolonged bleeding, and retained decidua cells were shown in 90%. By immunochemical stainning, LM and FN were both significantly expressed around the decidual cells and in the base membrane of blood vessels and glandular epithelium; and also within some of the decidual cells. The expression levels at the three locations had no significant differences between the 2 groups (P>0.05). The result illustrated that the retained decidua cells kept the function of secreting FN and LM, which served as the adhesion molecules to the uterine wall, thus caused prolonged uterine bleeding and postponed the regeneration of endometrium development.