CAJ | 학술논문

为观察健脑通络益智方对血管性痴呆大鼠脑部病理组织学的影响，探讨其治疗血管性痴呆的作用机理。从颈外动脉注射栓子造成多发性脑梗塞，加注山莨菪碱，以记忆力检测模型，测量各组大鼠脑内皮层、下丘脑、海马、纹状体部的病理组织学。结果：给药组大脑4个部位病变程度有不同程度改善，尤以大脑皮层明显。结论：健脑通络益智方具有减轻血管性痴呆动物脑内病变的作用。
위관찰건뇌통락익지방대혈관성치태대서뇌부병리조직학적영향，탐토기치료혈관성치태적작용궤리。종경외동맥주사전자조성다발성뇌경새，가주산랑탕감，이기억력검측모형，측량각조대서뇌내피층、하구뇌、해마、문상체부적병리조직학。결과：급약조대뇌4개부위병변정도유불동정도개선，우이대뇌피층명현。결론：건뇌통락익지방구유감경혈관성치태동물뇌내병변적작용。
To study the effects and mechanism of Jiannaotongluo Recipe on cerebral histopathology of vascular dementia rats. Methods:Multiple cerebral infarction was induced by injecting embolus through external carotid artery. Memory-detection model of anisodamine was established to determine the histopathology of cerebral cortex, hypothalamus, hippocampus and striate body of rats. Results: Pathological lesion of the four cerebral components of Jiannaotongluo Recipe groups was improved to a certain extent, especially for cerebral cortex. Conclusions: The reselts revealed that Jiannaotongluo Recipe could alleviate cerebral pathological lesion of vascular dementia animals.