CAJ | 학술논문

目的　检测喉鳞癌组织中基质金属蛋白酶-2(MMP-2)的表达情况，探讨其表达与喉癌临床病理关系。方法　应用免疫组化法，检测43例喉鳞癌组织中MMP 2的表达。结果　 43例喉鳞癌组织中，29例(67．4％)MMP-2表达阳性，其中颈淋巴结转移组明显高于无淋巴结转移组(P<0．05)，深部浸润的癌巢及基底膜附近的肿瘤细胞染色尤为明显。结论　 MMP-2能破坏基底膜，与喉癌浸润转移密切相关。
목적　검측후린암조직중기질금속단백매-2(MMP-2)적표체정황，탐토기표체여후암림상병리관계。방법　응용면역조화법，검측43례후린암조직중MMP 2적표체。결과　 43례후린암조직중，29례(67．4％)MMP-2표체양성，기중경림파결전이조명현고우무림파결전이조(P<0．05)，심부침윤적암소급기저막부근적종류세포염색우위명현。결론　 MMP-2능파배기저막，여후암침윤전이밀절상관。
Objective To study the relationship between the expression of matrix metallopro-teinase- 2(MMP- 2) and the clinical pathological characteristics of laryngeal squamous cell carcinoma.Methods Irnmunohistochemistry technique (ABC) was used to detect the expression and location ofMMP- 2 in the tissue of 43 cases with laryngeal squamous cell carcinoma. Results The positive ex-pression rate of the MMP - 2 protein was 29(67.4% ) among the 43 laryngeal tumor tissues. It was sig-nificantly related to metastasis of the cervical lymph nodes (P<0.05). MMP- 2 was immunolocalizedon the membranes and intracytoplasm of metastatic cluster tumor cells or the tumor cells adjacent to thebasement membrane. Conclusion These results suggest that MMP- 2 plays an important role in thetumor invasion and metastasis of laryngeal squamous cell carcinoma.