复旦学报(自然科学版)
複旦學報(自然科學版)
복단학보(자연과학판)
JOURNAL OF FUDAN UNIVERSITY(NATURAL SCIENCE)
2002年
1期
11-15
,共5页
葛晓春%宗晖%陈继超%杨武剑%曹凯鸣%孙崇荣
葛曉春%宗暉%陳繼超%楊武劍%曹凱鳴%孫崇榮
갈효춘%종휘%진계초%양무검%조개명%손숭영
人肿瘤抑制基因%顺式作用因子%胁迫诱导基因
人腫瘤抑製基因%順式作用因子%脅迫誘導基因
인종류억제기인%순식작용인자%협박유도기인
human tumor suppressor gene%cis-acting elements%stress-inducible gene
从水稻基因文库中筛选到一个与人类待定肿瘤抑制基因QM同源的基因,命名为OSQM2.该基因片断长为3.1kb,编码一个具有184个氨基酸的高度碱性的蛋白质.与其他已知QM基因相比,该基因具有一个非常特殊的启动子,包含许多在植物中已发现的与抗逆有关的顺式作用因子,如:"G盒","DRE盒","MYC盒"等,故而该基因有可能是一个新的受环境胁迫因子诱导的基因southern杂交表明它以单拷贝形式存在于基因组中.
從水稻基因文庫中篩選到一箇與人類待定腫瘤抑製基因QM同源的基因,命名為OSQM2.該基因片斷長為3.1kb,編碼一箇具有184箇氨基痠的高度堿性的蛋白質.與其他已知QM基因相比,該基因具有一箇非常特殊的啟動子,包含許多在植物中已髮現的與抗逆有關的順式作用因子,如:"G盒","DRE盒","MYC盒"等,故而該基因有可能是一箇新的受環境脅迫因子誘導的基因southern雜交錶明它以單拷貝形式存在于基因組中.
종수도기인문고중사선도일개여인류대정종류억제기인QM동원적기인,명명위OSQM2.해기인편단장위3.1kb,편마일개구유184개안기산적고도감성적단백질.여기타이지QM기인상비,해기인구유일개비상특수적계동자,포함허다재식물중이발현적여항역유관적순식작용인자,여:"G합","DRE합","MYC합"등,고이해기인유가능시일개신적수배경협박인자유도적기인southern잡교표명타이단고패형식존재우기인조중.
A gene homologous to the human putative tumor suppressor gene QM was isolated from rice genomic li-brary. It was designated OSQM2. The sequence was about 3.1 kb long and encoded a highly basic protein of 184amino acids. It has a very special promoter region compared with other known QM genes. Many known cis-acting ele-ments such as "G box", "DRE" box, "MYC" box can be found in its promoter region, so it is a putative new stress-inducible gene. Southern hybridization indicated that it existed in rice genome as a single copy gene.