CAJ | 학술논문

目的:研究信号转导和转录激活因子6(STAT6)在鼻息肉组织中的表达及其对嗜酸粒细胞(EOS)浸润聚集的作用,探讨其在鼻息肉发生中的可能作用.方法:选取符合纳入标准的鼻息肉患者手术切除标本(鼻息肉组)30例和同期单纯行鼻中隔偏曲矫正术中切除的下鼻甲组织(对照组)10例.采用免疫组织化学SP法检测2组下鼻甲黏膜中STAT6的表达.应用SPSS13.0软件进行统计学分析.结果:STAT6和EOS在鼻息肉组织中的表达明显高于下鼻甲,差异有统计学意义(P<0.05).STAT6阳性细胞主要集中于鼻息肉的上皮细胞、腺体细胞和组织中浸润的炎性细胞的细胞质中.鼻息肉组中STAT6的表达与EOS浸润程度一致(P<0.01).结论:STAT6在鼻息肉组织中的高表达及其对EOS浸润聚集的作用,可能与鼻息肉的发生和发展关系密切.
목적:연구신호전도화전록격활인자6(STAT6)재비식육조직중적표체급기대기산립세포(EOS)침윤취집적작용,탐토기재비식육발생중적가능작용.방법:선취부합납입표준적비식육환자수술절제표본(비식육조)30례화동기단순행비중격편곡교정술중절제적하비갑조직(대조조)10례.채용면역조직화학SP법검측2조하비갑점막중STAT6적표체.응용SPSS13.0연건진행통계학분석.결과:STAT6화EOS재비식육조직중적표체명현고우하비갑,차이유통계학의의(P<0.05).STAT6양성세포주요집중우비식육적상피세포、선체세포화조직중침윤적염성세포적세포질중.비식육조중STAT6적표체여EOS침윤정도일치(P<0.01).결론:STAT6재비식육조직중적고표체급기대EOS침윤취집적작용,가능여비식육적발생화발전관계밀절.
Objective:To study the distribution and expression of STAT6 and to examine the suggested roles of STAT6 in the pathogenesis of eosinophil infiltration in nasal polyps and to evaluate the role of STAT6 in the pathogenesis of nasal polyps.Method:All selected cases met the enrollment criteria.Thirty samples of nasal polyps were obtained from patients undergoing nasal polypectomy, and 10 samples of inferior turbinate tissues were from patients undergoing nasal septal reconstruction.STAT6 in nasal polyp tissues from 30 nasal polyposis patients and 10 samples of inferior turbinate tissues were detected with immunohistochemistry(SP) method.SPSS13.0 system was used to perform the statistical analysis.Result:The positive expression of STAT6 was significantly higher in epithelium of nasal polyps than that of the control. The number of eosinophils was significantly higher in epithelium of nasal polyps than that of the control. The difference between these two groups was statitically significant(P<0.05). STAT6 positive cell were localized on epithelium, gland cells and on inflammatory cell of nasal polyps. STAT6 expression was positively correlated with the recruitment of eosinophils in nasal polyps.Conclusion:The high expression of STAT6 protein and the suggested roles of STAT6 in the recruitment of eosinophils in nasal polyps may contribute to the initiation and progression of nasal polyps.