应用化工
應用化工
응용화공
APPLIED CHEMICAL INDUSTRY
2010年
1期
93-95
,共3页
合成%3-甲基-喹噁啉-2-羧酸%喹乙醇%还原
閤成%3-甲基-喹噁啉-2-羧痠%喹乙醇%還原
합성%3-갑기-규오람-2-최산%규을순%환원
synthesis%3-methylquinoxaline-2-carboxylic acid%olaquindox%reduction
以喹乙醇为原料,经酸性还原,碱性水解、中和后得到3-甲基-喹噁啉-2-羧酸,探讨了反应条件对产率的影响.结果表明,喹乙醇在铁粉的酸性水溶液中活化后,85～90 ℃还原1 h,有机溶剂萃取得到N-羟乙基-3-甲基-2-喹噁啉酰胺,而后在12%氢氧化钠溶液中80～90 ℃水解6 h,盐酸酸化,得到纯度大于98%的3-甲基-喹噁啉-2-羧酸,总收率为60.6%.
以喹乙醇為原料,經痠性還原,堿性水解、中和後得到3-甲基-喹噁啉-2-羧痠,探討瞭反應條件對產率的影響.結果錶明,喹乙醇在鐵粉的痠性水溶液中活化後,85～90 ℃還原1 h,有機溶劑萃取得到N-羥乙基-3-甲基-2-喹噁啉酰胺,而後在12%氫氧化鈉溶液中80～90 ℃水解6 h,鹽痠痠化,得到純度大于98%的3-甲基-喹噁啉-2-羧痠,總收率為60.6%.
이규을순위원료,경산성환원,감성수해、중화후득도3-갑기-규오람-2-최산,탐토료반응조건대산솔적영향.결과표명,규을순재철분적산성수용액중활화후,85～90 ℃환원1 h,유궤용제췌취득도N-간을기-3-갑기-2-규오람선알,이후재12%경양화납용액중80～90 ℃수해6 h,염산산화,득도순도대우98%적3-갑기-규오람-2-최산,총수솔위60.6%.
3-Methylquinoxaline-2-carboxylic acid was synthesized from olaquindox by reduction,hydrolysis and subsequent neutralization.The influence of reaction conditions was investigated.The results showed that the olaquindox were reducted in the solution of acid activative iron,then N-(hydroxy-ethyl)-3-methyl-2-quinoxaline was obtained by reduction at 85～90 ℃ for 1 h and extracted with solvent.3-Methylquinoxaline-2-carboxylic acid was obtained with an overall yield of 60.6% by hydrolysis at 80～90 ℃ for 6 h and acid with hydrogen chloride.
